{"id":"W4361298593","doi":"10.1073/pnas.2213771120","title":"Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Office of Science; Argonne National Laboratory; National Institute of General Medical Sciences; Burroughs Wellcome Fund; U.S. Department of Energy","keywords":"Biochemistry; Enzyme; Hydrolase; Biology; Nucleotide; In silico; Bacteria; Guanosine; Adenosine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002046198,0.00008070792,0.0001884746,0.0002245226,0.0001140935,0.00001759845,0.0007104716,0.00007887083,0.00002430374],"category_scores_gemma":[0.0005161714,0.00005520593,0.00008096797,0.001092049,0.0009701519,0.0004658833,0.0001134407,0.00007035673,0.00000432198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001362735,"about_ca_system_score_gemma":0.00004213798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002014068,"about_ca_topic_score_gemma":1.52887e-7,"domain_scores_codex":[0.9978877,0.00001093469,0.0005009979,0.0002192622,0.00125341,0.0001276814],"domain_scores_gemma":[0.9985,0.0001486651,0.0009566247,0.00001521616,0.0003587555,0.00002067351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001851099,0.00001445592,0.003258818,0.000104044,0.000005946932,1.772865e-9,0.000244539,0.0001021576,0.9735043,0.02150263,0.001170235,0.00007437886],"study_design_scores_gemma":[0.0001096978,0.00003004993,0.1027046,0.00005738544,0.00001174887,0.000001479766,0.0003403573,0.0005320084,0.8680834,0.02803739,0.00004558811,0.00004624967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969382,0.0001231395,0.000002577844,0.0006618942,0.00007600146,0.0001421282,0.00003966847,0.00002073037,0.001995675],"genre_scores_gemma":[0.9993907,0.00002983745,0.0002692748,0.00006325162,0.00003889701,0.000007308963,3.036756e-7,0.000003449993,0.0001969614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1054209,"threshold_uncertainty_score":0.3574565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05107714022920716,"score_gpt":0.2955959057378335,"score_spread":0.2445187655086263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}