{"id":"W4361298909","doi":"10.1101/2023.03.27.534417","title":"Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Weill Cornell Medical College; National Institutes of Health; New York State Stem Cell Science; American Society of Hematology","keywords":"Cell biology; Haematopoiesis; Progenitor cell; Regenerative medicine; Niche; Stem cell; Biology; Signal transduction; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007786383,0.0001602742,0.0001103301,0.0001257089,0.00008568174,0.0002725797,0.00007424887,0.0001481138,0.001128729],"category_scores_gemma":[0.00006142813,0.00008549638,0.0001024361,0.00009677069,0.0002277988,0.000144209,0.0001562009,0.0002402252,0.00025124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001788812,"about_ca_system_score_gemma":0.0001204751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000178732,"about_ca_topic_score_gemma":0.0003830153,"domain_scores_codex":[0.9999377,0.000006685128,0.000002192418,0.00002060153,0.00001718898,0.00001573737],"domain_scores_gemma":[0.9999678,0.000006010194,0.000008751053,0.000004725412,0.0000033885,0.00000935843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001546736,0.000002239959,0.0001099679,0.000006546571,4.918969e-7,0.000009420833,0.000005775692,0.00002443305,0.9990097,0.0001096796,0.00001928037,0.0006868719],"study_design_scores_gemma":[0.000003977475,0.000032035,0.005895974,0.000002834079,0.00000304189,0.00008307938,0.00001992983,0.001269155,0.9911879,0.0001858286,0.001313852,0.00000220644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872149,0.0006045169,0.009367796,0.00009397502,0.0000161983,0.00001116054,0.0005716403,0.0001713607,0.001948402],"genre_scores_gemma":[0.9934266,0.0002902895,0.002689155,0.00003982706,0.000007293987,0.00001676182,0.0005559988,0.00002764263,0.002946506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128729,"threshold_uncertainty_score":0.003776014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071249753645197,"score_gpt":0.2183202772706934,"score_spread":0.1976077797342414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}