{"id":"W4361299200","doi":"10.1080/15592294.2023.2192375","title":"Phenotypic and transcriptomic impact of expressing mammalian TET2 in the<i>Drosophila melanogaster</i>model","year":2023,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Génome Québec; Cancer Research Society; American University of Beirut","keywords":"Biology; Drosophila melanogaster; Transcriptome; Mutant; Phenotype; Innate immune system; Mutation; Genetics; Cell biology; Schneider 2 cells; Gene knockdown; Gene; Carcinogenesis; Epigenetics; Immune system; RNA interference; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003454543,0.0001464564,0.0001495544,0.00008485158,0.00005235772,0.00002379278,0.0001821963,0.0001227781,0.000003493586],"category_scores_gemma":[0.00003503746,0.0001175214,0.00008957518,0.0001784847,0.00008440096,0.000003254639,0.00005008957,0.00008108719,0.000002831395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008562924,"about_ca_system_score_gemma":0.00005402707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002492848,"about_ca_topic_score_gemma":0.00004994648,"domain_scores_codex":[0.9990144,0.00009048207,0.0002647619,0.0002473477,0.0001381767,0.0002447736],"domain_scores_gemma":[0.9994939,0.0000241471,0.00007417618,0.0003242519,0.00003421876,0.00004933511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003311961,0.00003081304,0.01996583,0.00002229509,0.00001569017,0.000002125433,0.0007520565,0.01183588,0.9645144,0.00003834637,0.00005160437,0.002737845],"study_design_scores_gemma":[0.001505008,0.0007433437,0.3997567,0.00005135924,0.00005392465,0.000005603833,0.0003322112,0.01622304,0.5737278,0.006090735,0.00103554,0.0004747387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957397,0.002023162,0.001304837,0.00009067749,0.00005240954,0.0001670966,0.0000333872,0.00000744203,0.0005813172],"genre_scores_gemma":[0.9979608,0.0009941871,0.0007273022,0.00003163352,0.00007801788,0.00001060554,0.00006651926,0.00002379013,0.0001071338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3907866,"threshold_uncertainty_score":0.4792383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237638381340686,"score_gpt":0.2950232281100004,"score_spread":0.2712593899759319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}