{"id":"W4361301668","doi":"10.1002/hbm.26291","title":"Altered large‐scale dynamic connectivity patterns in Alzheimer's disease and mild cognitive impairment patients: A machine learning study","year":2023,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Beijing Municipal Natural Science Foundation; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; Fundamental Research Funds for the Central Universities; National Institutes of Health; Eisai Canada; IXICO; H. Lundbeck A/S; Servier; Eisai; National Natural Science Foundation of China; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; Pfizer; Biogen; BioClinica; Takeda Pharmaceuticals U.S.A.; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Merck; Alzheimer's Drug Discovery Foundation; AbbVie; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Default mode network; Cognition; Dynamic functional connectivity; Context (archaeology); Resting state fMRI; Neuroscience; Psychology; Receiver operating characteristic; Functional connectivity; Alzheimer's disease; Cognitive decline; Disease; Artificial intelligence; Dementia; Computer science; Machine learning; Medicine; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001283818,0.0004658669,0.0004874697,0.001241753,0.0003584322,0.0005218586,0.0003771632,0.0004689521,0.0006784694],"category_scores_gemma":[0.003816035,0.0001401378,0.0006401611,0.0008505255,0.0003429345,0.0004249439,0.0004294137,0.0004592418,0.0001535611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002326329,"about_ca_system_score_gemma":0.0002724532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00282566,"about_ca_topic_score_gemma":0.002596973,"domain_scores_codex":[0.9996712,0.00009782464,0.00003558588,0.000110269,0.00004026502,0.00004476099],"domain_scores_gemma":[0.9990252,0.0005197775,0.0001384135,0.0001262127,0.0000863536,0.0001040891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001253885,0.0005448811,0.9326683,0.00007126043,0.0005905362,0.0004393971,0.0003806307,0.004663968,0.002446476,0.0002095679,0.0006531415,0.05607813],"study_design_scores_gemma":[0.00003309466,0.0003604799,0.9400177,0.00001412563,0.0001588369,0.0005484572,0.0002254451,0.05726222,0.0004701006,0.0005870179,0.000300379,0.00002210301],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982163,0.0001452486,0.001222177,0.00005124659,0.000007867849,0.0000176394,0.0001717446,0.00001034956,0.0001574726],"genre_scores_gemma":[0.9988299,0.00006483097,0.0006016729,0.00001021085,0.00001336644,0.00001468334,0.0003956196,0.000002442243,0.0000672763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00282566,"threshold_uncertainty_score":0.006789565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04580357267530244,"score_gpt":0.2995902357074264,"score_spread":0.253786663032124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}