{"id":"W4361301818","doi":"10.1515/cclm-2022-1305","title":"First-trimester screening for Down syndrome using quadruple maternal biochemical markers","year":2023,"lang":"en","type":"article","venue":"Clinical Chemistry and Laboratory Medicine (CCLM)","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université Laval","funders":"","keywords":"Medicine; Obstetrics; Preeclampsia; Down syndrome; False positive rate; Placental growth factor; Receiver operating characteristic; Gestational age; Pregnancy; Pregnancy-associated plasma protein A; Gynecology; Human chorionic gonadotropin; Alpha-fetoprotein; Fetus; Internal medicine; First trimester; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020137,0.0005449763,0.0004840848,0.001079328,0.0001525107,0.0003760316,0.0003445729,0.0003861873,0.001206854],"category_scores_gemma":[0.003324393,0.0002103581,0.0002994615,0.000559195,0.0001800481,0.0002259459,0.000305381,0.000402847,0.0002380666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002920072,"about_ca_system_score_gemma":0.0002091168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001797745,"about_ca_topic_score_gemma":0.002073645,"domain_scores_codex":[0.9990236,0.0003502455,0.00006439129,0.0002122018,0.0002811174,0.00006845578],"domain_scores_gemma":[0.9986473,0.0004147231,0.0006188893,0.0000534203,0.0001543533,0.0001112632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003421427,0.0000483089,0.977029,0.00006980013,0.00009159239,0.0002033101,0.00005907708,0.0001602938,0.004730347,0.00002952473,0.000170764,0.01706588],"study_design_scores_gemma":[0.00004004091,0.001053151,0.9812305,0.0001026778,0.0001714185,0.003971986,0.00005831221,0.004489867,0.007940125,0.0001106981,0.0008130532,0.00001817605],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934292,0.00235231,0.002534659,0.0001607811,0.00002575215,0.0000348113,0.0005053553,0.00007157476,0.0008855464],"genre_scores_gemma":[0.9955107,0.0005116409,0.003297492,0.00003843804,0.00001295817,0.00002062804,0.0002015579,0.000003732059,0.0004028509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797745,"threshold_uncertainty_score":0.005395055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06555044631789055,"score_gpt":0.3684217087614304,"score_spread":0.3028712624435399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}