{"id":"W4361301818","doi":"10.1515/cclm-2022-1305","title":"First-trimester screening for Down syndrome using quadruple maternal biochemical markers","year":2023,"lang":"en","type":"article","venue":"Clinical Chemistry and Laboratory Medicine (CCLM)","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université Laval","funders":"","keywords":"Medicine; Obstetrics; Preeclampsia; Down syndrome; False positive rate; Placental growth factor; Receiver operating characteristic; Gestational age; Pregnancy; Pregnancy-associated plasma protein A; Gynecology; Human chorionic gonadotropin; Alpha-fetoprotein; Fetus; Internal medicine; First trimester; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001217557,0.0002925625,0.0007127644,0.00004658948,0.000167754,0.00002265384,0.0001610426,0.0004204597,0.0001852241],"category_scores_gemma":[0.004461386,0.0002396341,0.0001422464,0.0004279573,0.0005482134,0.00007419544,0.0001348073,0.0005153274,0.00001685368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003078343,"about_ca_system_score_gemma":0.0001426653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002972325,"about_ca_topic_score_gemma":4.712232e-7,"domain_scores_codex":[0.9977548,0.00004403506,0.0007910446,0.0005969765,0.000325365,0.0004877674],"domain_scores_gemma":[0.9969156,0.001614514,0.0001831868,0.0003979867,0.0001898428,0.0006988413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006241491,0.0005916516,0.6740642,0.007092575,0.001118191,0.003066465,0.0002662733,0.0001026446,0.05839308,0.00005644077,0.2435039,0.00550309],"study_design_scores_gemma":[0.04856684,0.004227087,0.6599612,0.01626153,0.003702914,0.002365552,0.002259595,0.0388255,0.06790449,0.0006026468,0.152234,0.00308866],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948965,0.0008487392,0.0008027503,0.00218294,0.0002844175,0.0003071424,0.0001262283,0.0002286523,0.0003226125],"genre_scores_gemma":[0.9926875,0.000257199,0.00315569,0.001244482,0.001471874,0.00003256381,0.0002500095,0.00005837766,0.0008423265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09126987,"threshold_uncertainty_score":0.9771994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06555044631789055,"score_gpt":0.3684217087614304,"score_spread":0.3028712624435399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}