{"id":"W4361304261","doi":"10.1002/biot.202200575","title":"Isolation of extracellular vesicles from human plasma samples: The importance of controls","year":2023,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"McGill University Health Centre","keywords":"Centrifugation; Chemistry; Chromatography; Human plasma; Yield (engineering); Contamination; Extracellular; Lysis; Extracellular vesicles; Recombinant DNA; Biochemistry; Biology; Materials science; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004458047,0.0001295548,0.0002001253,0.0001030004,0.000131886,0.00001115797,0.0005114693,0.0003507904,0.00003859321],"category_scores_gemma":[0.000263369,0.0001026084,0.000147816,0.0001913714,0.0004349631,0.000005588567,0.0001314418,0.0002440499,0.000007103647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001069178,"about_ca_system_score_gemma":0.00006214786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009693509,"about_ca_topic_score_gemma":0.00001995741,"domain_scores_codex":[0.9987974,0.00008693198,0.0005233095,0.0002121613,0.0001607876,0.000219408],"domain_scores_gemma":[0.9987801,0.00004806758,0.0005209704,0.0005186397,0.00008497421,0.00004727719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006400998,0.00004481793,0.02331507,0.000007171656,0.0001080814,0.00001341357,0.00003336617,0.00005633924,0.9730154,0.001278509,0.0008133611,0.001250435],"study_design_scores_gemma":[0.0007493846,0.0002042378,0.01450081,0.0000234088,0.00004959774,0.00003504255,0.0003462008,0.0002307075,0.9766604,0.0045335,0.002552299,0.0001143908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906669,0.003792735,0.004422976,0.0007548446,0.0001100573,0.0001281778,0.00006198425,0.00002718914,0.00003510414],"genre_scores_gemma":[0.9977202,0.000382114,0.001556231,0.00003008202,0.0001495894,0.000005374028,0.00006291994,0.00002057781,0.0000729466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008814265,"threshold_uncertainty_score":0.4184251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649002662943752,"score_gpt":0.2597212472789568,"score_spread":0.2432312206495193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}