{"id":"W4361306699","doi":"10.1016/j.heliyon.2023.e14999","title":"Modelling hyperexcitability in human cerebral cortical organoids: Oxygen/glucose deprivation most effective stimulant","year":2023,"lang":"en","type":"article","venue":"Heliyon","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Krembil Foundation; University of Toronto","funders":"","keywords":"Stimulant; Human brain; Neuroscience; Organoid; Psychology; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713641,0.0003640689,0.0003383984,0.0001907577,0.0001685946,0.0003165329,0.0002603348,0.0003526524,0.000617589],"category_scores_gemma":[0.0001530912,0.0001019588,0.0003812781,0.0001987174,0.0002632187,0.0002519899,0.0003419167,0.0006803345,0.0001951294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791737,"about_ca_system_score_gemma":0.0002555816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001288771,"about_ca_topic_score_gemma":0.002249441,"domain_scores_codex":[0.9998143,0.00002104179,0.00002181696,0.00005711136,0.00005933456,0.0000263649],"domain_scores_gemma":[0.9998862,0.0000281651,0.00002594342,0.00001808895,0.00002154959,0.00002000779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007268976,0.00002396409,0.0002584543,0.0001441568,0.00001086344,0.0002282455,0.00008740557,0.0005791662,0.9962004,0.0001467382,0.0001113924,0.002136671],"study_design_scores_gemma":[0.000008139746,0.0003764152,0.002723572,0.00002129042,0.00003292459,0.0004203099,0.0001103891,0.001264515,0.989561,0.0001092692,0.005359549,0.00001271648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9522495,0.006037602,0.03441868,0.0003138441,0.0001787018,0.0001942057,0.001570373,0.0002323061,0.004804742],"genre_scores_gemma":[0.9824452,0.003921792,0.009947773,0.0001325941,0.00001201915,0.0003021916,0.001026095,0.00004298169,0.002169326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288771,"threshold_uncertainty_score":0.002562523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07014381827353311,"score_gpt":0.3513334226356881,"score_spread":0.281189604362155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}