{"id":"W4361800518","doi":"10.2139/ssrn.4397238","title":"Development of an Inducible Cas9 Nickase and Pam-Free Cas12a Platform for Bacterial Diagnostics","year":2023,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Biosensors and Analytical Detection","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Government of Canada; Agriculture and Agri-Food Canada","funders":"","keywords":"CRISPR; Cas9; Computational biology; Genome editing; Biology; Genetics; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00052374,0.0001019359,0.0001400333,0.0001071004,0.0001076445,0.00002925499,0.00009356067,0.00008522175,0.0000074774],"category_scores_gemma":[0.00009098644,0.00009251766,0.00003858023,0.0001410942,0.00001666317,0.0001159726,0.00002226804,0.0004131524,0.00000382423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918662,"about_ca_system_score_gemma":0.0002473377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007633719,"about_ca_topic_score_gemma":0.0007623163,"domain_scores_codex":[0.9987171,0.000006020315,0.0002451221,0.00009768683,0.0001061041,0.0008279582],"domain_scores_gemma":[0.9996867,0.00005541549,0.00003791539,0.00009957374,0.00003520376,0.00008517571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003947972,0.0002028227,0.0003533062,0.0004001464,0.001044652,0.00003577146,0.002107123,0.002612966,0.1394681,0.03467257,0.001449503,0.8172582],"study_design_scores_gemma":[0.01486334,0.004226011,0.0115997,0.0003868143,0.000564731,0.001940302,0.009804216,0.1673886,0.340297,0.3936613,0.05248199,0.0027859],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970971,0.0001897944,0.002245473,0.00003666287,0.0002395995,0.00008276526,0.00001314087,0.0000553731,0.00004011124],"genre_scores_gemma":[0.9972097,0.001482478,0.0009204164,0.000004748204,0.0002618203,0.000005696762,0.00001373838,0.00002594326,0.00007543588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8144723,"threshold_uncertainty_score":0.3772761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513603869843186,"score_gpt":0.2288565882175782,"score_spread":0.2137205495191464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}