{"id":"W4361810560","doi":"10.1158/0008-5472.c.6512425.v1","title":"Data from Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Rutgers Cancer Institute of New Jersey; Princeton University; Brewster Foundation; U.S. Department of Defense","keywords":"Colorectal cancer; Cancer research; Metastasis; Medicine; Lung; Wnt signaling pathway; In vivo; Lung cancer; Cancer; Oncology; Internal medicine; Biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003184422,0.0002577033,0.0007189675,0.0000839719,0.00004504039,0.00004634398,0.0001858096,0.0001703481,0.0007208143],"category_scores_gemma":[0.00003166312,0.0001855065,0.00005700127,0.00008381691,0.00008076628,0.00006995929,0.001124401,0.0002988881,5.930373e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002673593,"about_ca_system_score_gemma":0.0001572754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003115711,"about_ca_topic_score_gemma":0.0006034821,"domain_scores_codex":[0.9984584,0.00006014723,0.0003311823,0.0006891933,0.0002733731,0.0001877386],"domain_scores_gemma":[0.9989468,0.0001374285,0.000205863,0.0005370157,0.0000751864,0.0000976817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003779395,0.0005318427,0.05340765,0.007389121,0.01670167,0.0001332962,0.003159385,0.00004856019,0.6188455,0.0008034629,0.009812473,0.2853876],"study_design_scores_gemma":[0.0107675,0.001294013,0.0842923,0.00752366,0.01480098,0.00003348005,0.002798935,0.07971198,0.766123,0.01072161,0.01958208,0.002350484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.882197,0.1098256,0.001437137,0.001237658,0.0007234357,0.001295016,0.003031186,0.0001463837,0.0001065764],"genre_scores_gemma":[0.9617635,0.02398014,0.01210329,0.0001307603,0.0002781007,0.0001808062,0.001175673,0.00008857346,0.0002991579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2830372,"threshold_uncertainty_score":0.7892411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09811065370610701,"score_gpt":0.4028986731950989,"score_spread":0.3047880194889919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}