{"id":"W4361813684","doi":"10.1158/1535-7163.c.6532185","title":"Data from Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent &lt;i&gt;O&lt;/i&gt;&lt;sup&gt;6&lt;/sup&gt;-methylguanine-DNA methyltransferase","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; BC Cancer Agency; Child and Family Research Institute; McGill University; University of British Columbia","funders":"C17 Council; Cancer Research Society","keywords":"Temozolomide; Glioblastoma; Cancer research; Methyltransferase; Brain tumor; Medicine; Downregulation and upregulation; Internal medicine; Chemistry; Gene; Oncology; Pathology; Methylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003058862,0.0006792034,0.0007872263,0.0004119714,0.000270141,0.0003295185,0.0004101297,0.0004352368,0.006259536],"category_scores_gemma":[0.0002781752,0.0002132677,0.000748146,0.0002994807,0.0002519935,0.0003534563,0.0002236655,0.001713295,0.001639848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005320008,"about_ca_system_score_gemma":0.0005833193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00212858,"about_ca_topic_score_gemma":0.003273119,"domain_scores_codex":[0.9997811,0.0000243431,0.00002833566,0.00003510766,0.00006776362,0.00006329922],"domain_scores_gemma":[0.9998216,0.00002831498,0.00002582942,0.00002343779,0.00004812294,0.00005261448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006471991,0.001502149,0.002255811,0.0008602202,0.000234614,0.0003030857,0.0001087996,0.000544965,0.9417317,0.0007176806,0.01147986,0.03378911],"study_design_scores_gemma":[0.0008411972,0.008018767,0.02951546,0.00005912984,0.0003026156,0.0009075287,0.000140611,0.001712586,0.9101902,0.0003432025,0.04792053,0.00004810703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9445951,0.02114997,0.002561938,0.003419765,0.001376678,0.0001897585,0.01239505,0.0006547053,0.01365705],"genre_scores_gemma":[0.9495064,0.01268707,0.002509124,0.001460013,0.0001085069,0.0003035228,0.01373853,0.0001087799,0.019578],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.006259536,"threshold_uncertainty_score":0.02094024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03316110618506696,"score_gpt":0.2780072493289564,"score_spread":0.2448461431438895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}