{"id":"W4361817471","doi":"10.1158/1078-0432.c.6530853","title":"Data from Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Discontinuation; Medicine; Regimen; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002245825,0.001062579,0.001593366,0.0002832208,0.0003263938,0.001119786,0.000705733,0.0009318254,0.003492519],"category_scores_gemma":[0.0009180256,0.0003542636,0.001501612,0.0004210309,0.0005626233,0.0008456708,0.0002775114,0.002892012,0.0009180663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007133638,"about_ca_system_score_gemma":0.001385871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007956499,"about_ca_topic_score_gemma":0.002453051,"domain_scores_codex":[0.9993532,0.0002812775,0.00007222053,0.00008623501,0.0001155367,0.00009145583],"domain_scores_gemma":[0.9989179,0.0002460753,0.000230045,0.0001366257,0.0001174678,0.0003519246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4723939,0.04646388,0.01352685,0.00327284,0.005182421,0.0005271057,0.0003853939,0.00433919,0.2250367,0.0007311825,0.02378069,0.2043598],"study_design_scores_gemma":[0.330715,0.5121891,0.05280295,0.0002862481,0.005601522,0.001445577,0.0002723017,0.002107166,0.05548043,0.00057736,0.03840652,0.0001158761],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9632264,0.01114302,0.002294279,0.001682612,0.0003510396,0.002970526,0.009203664,0.0002296512,0.008898762],"genre_scores_gemma":[0.9719967,0.005308528,0.002643636,0.002054516,0.0001714433,0.002179986,0.01146239,0.00007628895,0.004106442],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.003492519,"threshold_uncertainty_score":0.01187724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0942066740050742,"score_gpt":0.359705631009887,"score_spread":0.2654989570048128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}