{"id":"W4361817471","doi":"10.1158/1078-0432.c.6530853","title":"Data from Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Discontinuation; Medicine; Regimen; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001715256,0.0006398161,0.00166931,0.0001321318,0.00009113662,0.00002587185,0.0003725615,0.0001744606,0.00007577979],"category_scores_gemma":[0.0001328936,0.0003122094,0.00007437088,0.000187116,0.0004295844,0.00009125466,0.0003541001,0.0002371404,2.31394e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000683952,"about_ca_system_score_gemma":0.0002143766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003417665,"about_ca_topic_score_gemma":0.001957837,"domain_scores_codex":[0.9966125,0.0001402372,0.001139751,0.001220477,0.0005703347,0.0003166641],"domain_scores_gemma":[0.9951416,0.001398132,0.001319973,0.001556659,0.0004501519,0.0001335373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.384213,0.04211183,0.4009203,0.001863325,0.03796522,0.00007642193,0.04522227,0.0002525038,0.002363103,0.000003427695,0.000300025,0.08470859],"study_design_scores_gemma":[0.3363255,0.04145375,0.4825829,0.004953748,0.01517099,0.000003593238,0.01791637,0.01667221,0.08290336,0.0002695246,0.0002889195,0.001459084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589306,0.001161095,0.003441826,0.00009573688,0.0001070013,0.006998471,0.0291858,0.00007510372,0.000004335187],"genre_scores_gemma":[0.9735507,0.0001247398,0.004995821,0.000009398464,0.00009050487,0.0002575122,0.02072733,0.0001109514,0.0001330885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08324951,"threshold_uncertainty_score":0.999933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0942066740050742,"score_gpt":0.359705631009887,"score_spread":0.2654989570048128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}