{"id":"W4361822139","doi":"10.1158/0008-5472.c.6499160.v1","title":"Data from Modification of Ovarian Cancer Risk by &lt;i&gt;BRCA1/2&lt;/i&gt;-Interacting Genes in a Multicenter Cohort of &lt;i&gt;BRCA1/2&lt;/i&gt; Mutation Carriers","year":2023,"lang":"en","type":"preprint","venue":"","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital","funders":"University of California, Los Angeles; Medical Research Council; Universität Wien; Creighton University; Jonsson Comprehensive Cancer Center; Women's College Hospital; Nebraska Department of Health and Human Services; National Health and Medical Research Council; Georgetown University; Northwestern University; National Breast Cancer Foundation; City of Hope; University of Pennsylvania; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Haplotype; Medicine; Internal medicine; Biology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009963822,0.0002573632,0.0003882737,0.0007650888,0.0003283995,0.0005008958,0.0004259514,0.0003869291,0.002299371],"category_scores_gemma":[0.003385928,0.0002482088,0.0008926233,0.001330564,0.0002114704,0.0002639241,0.0003824474,0.0003090789,0.000431114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003218821,"about_ca_system_score_gemma":0.0003112199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01005614,"about_ca_topic_score_gemma":0.005867644,"domain_scores_codex":[0.9992058,0.0002221681,0.00008464231,0.0002810713,0.0001337013,0.00007267476],"domain_scores_gemma":[0.996358,0.0005617845,0.001512998,0.0009920859,0.0002745565,0.0003005098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001082873,0.00002449384,0.9945177,0.00002069402,0.0002852789,0.00009480409,0.00005232998,0.0001009927,0.00110363,0.00004123991,0.0004809469,0.002194989],"study_design_scores_gemma":[0.00006158722,0.0002307987,0.997201,0.000007205513,0.00028997,0.0002826673,0.00004007932,0.0001562096,0.0004386652,0.00004784978,0.001237425,0.000006720666],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9896513,0.0003794551,0.0005183018,0.00006210952,0.00001347259,0.00004085357,0.007937212,0.00002245761,0.001374847],"genre_scores_gemma":[0.992957,0.000178093,0.0002612983,0.00007626112,0.00001647979,0.00007307485,0.005601876,0.00002187544,0.0008140525],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.01005614,"threshold_uncertainty_score":0.01999521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03248878709679728,"score_gpt":0.3146342833297054,"score_spread":0.2821454962329082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}