{"id":"W4361822496","doi":"10.1158/0008-5472.c.6503241.v1","title":"Data from Cell-Cycle Regulator Cks1 Promotes Hepatocellular Carcinoma by Supporting NF-κB–Dependent Expression of Interleukin-8","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Downregulation and upregulation; Gene knockdown; Cancer research; Regulator; Cell cycle; Ectopic expression; Ubiquitin; Biology; Cell growth; Chemistry; Cell; Cell culture; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346156,0.0005933329,0.000592993,0.0008467464,0.000457351,0.0006181661,0.0003891972,0.0004577822,0.02904653],"category_scores_gemma":[0.0002609937,0.0001969132,0.0006621769,0.0005963109,0.0003855979,0.0004544017,0.0003923413,0.001541782,0.008231904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006155047,"about_ca_system_score_gemma":0.0005332919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001752607,"about_ca_topic_score_gemma":0.001705607,"domain_scores_codex":[0.9995872,0.00002605038,0.00005310823,0.00008365111,0.000160218,0.00008970115],"domain_scores_gemma":[0.9996428,0.00005511587,0.00005019156,0.00006174251,0.00008963918,0.0001005503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001739236,0.000334002,0.001265717,0.0005892144,0.00006556021,0.0002865667,0.00005667603,0.0002268484,0.9750397,0.0007662002,0.007639294,0.01199098],"study_design_scores_gemma":[0.0001581765,0.0005601012,0.0357844,0.00005925862,0.00006684347,0.0006922279,0.0001606672,0.001339657,0.8833326,0.0003426447,0.07747853,0.00002504687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.7547345,0.02501819,0.01506871,0.006723522,0.003681257,0.0002772295,0.1097727,0.004111583,0.08061234],"genre_scores_gemma":[0.8196105,0.01018041,0.007084153,0.001520568,0.0003463808,0.0004943439,0.08583396,0.000434062,0.07449563],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.02904653,"threshold_uncertainty_score":0.09717035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05018181840416693,"score_gpt":0.2935984365793164,"score_spread":0.2434166181751495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}