{"id":"W4361822765","doi":"10.1158/0008-5472.c.6500066.v1","title":"Data from β&lt;sub&gt;1&lt;/sub&gt;-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2–Positive Breast Cancer","year":2023,"lang":"en","type":"preprint","venue":"","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of California, Los Angeles; Alberta Cancer Foundation; Cancer Research Institute","keywords":"Trastuzumab; Cancer research; Protein kinase B; Breast cancer; Integrin; Epidermal growth factor receptor; Metastatic breast cancer; PI3K/AKT/mTOR pathway; Growth factor receptor; Cancer; Medicine; Internal medicine; Biology; Receptor; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003047992,0.0003112324,0.0004659498,0.0002646102,0.0002313855,0.0004411612,0.000269324,0.0004116108,0.003497605],"category_scores_gemma":[0.0002801856,0.0001498033,0.0003963855,0.0002620107,0.0001970394,0.0001874713,0.0001217905,0.001079386,0.0009892436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003582108,"about_ca_system_score_gemma":0.0003641515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001538406,"about_ca_topic_score_gemma":0.001678244,"domain_scores_codex":[0.9996406,0.0000611557,0.00004612538,0.00004430272,0.0001288275,0.00007905521],"domain_scores_gemma":[0.9998394,0.00004235112,0.00001723239,0.00003316502,0.00002634259,0.00004137889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001378875,0.0004226245,0.0005375945,0.0001070569,0.00003543532,0.0001047507,0.00003585452,0.0002766505,0.9889222,0.0002866618,0.001907876,0.005984434],"study_design_scores_gemma":[0.0003061156,0.001996529,0.01438418,0.000009804559,0.00007457618,0.0007085061,0.00005966197,0.001613591,0.955748,0.0001531163,0.02493135,0.00001456813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9761325,0.003482879,0.00222328,0.001072508,0.0003168815,0.0001202958,0.006925357,0.000175045,0.009551234],"genre_scores_gemma":[0.9731923,0.002042966,0.001741091,0.00048556,0.00004273317,0.0001833718,0.01258506,0.00006670655,0.009660167],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.003497605,"threshold_uncertainty_score":0.01170063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08616599863725775,"score_gpt":0.3870258860101897,"score_spread":0.300859887372932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}