{"id":"W4361822828","doi":"10.1158/0008-5472.c.6499386.v1","title":"Data from PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A–Mediated Inactivation in Human Malignant Glioma","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Pirkanmaan Sairaanhoitopiiri; Emil Aaltosen Säätiö; Helsingin ja Uudenmaan Sairaanhoitopiiri; Damon Runyon Cancer Research Foundation","keywords":"MAPK/ERK pathway; Kinase; Signal transduction; Phosphatase; Protein kinase A; Protein phosphatase 1; c-Raf; Cancer research; Cell biology; Biology; Protein phosphatase 2; Phosphorylation; Chemistry; Mitogen-activated protein kinase kinase; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002175762,0.0005598809,0.0003857437,0.0004874634,0.0002255698,0.0002120675,0.0002417979,0.0002790361,0.002799967],"category_scores_gemma":[0.0001378647,0.0001884653,0.0004899921,0.0003068881,0.0002237681,0.0001779166,0.0001726153,0.0007465179,0.0009270466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003267615,"about_ca_system_score_gemma":0.0002418834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001467667,"about_ca_topic_score_gemma":0.001431938,"domain_scores_codex":[0.9998265,0.00004017208,0.00001916553,0.00002133674,0.00005663016,0.00003624434],"domain_scores_gemma":[0.9999171,0.00001669821,0.0000120764,0.00001792964,0.00001231001,0.00002394049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009498351,0.0003124014,0.0003748177,0.0001531453,0.00002934069,0.0001251609,0.00003136661,0.0002121854,0.9924713,0.0001751402,0.0005416691,0.004623623],"study_design_scores_gemma":[0.00009333709,0.001317571,0.008376575,0.000005951871,0.0000397463,0.0004915193,0.0000272951,0.0006997269,0.9841267,0.00006871425,0.004745692,0.000007001136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9831314,0.005212907,0.003227128,0.0004410595,0.00007997725,0.00008487253,0.003095125,0.0001992863,0.004528353],"genre_scores_gemma":[0.9774612,0.003612044,0.002744736,0.0001377009,0.00002382758,0.0001741069,0.009894193,0.00004502544,0.005907256],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.002799967,"threshold_uncertainty_score":0.00936681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05559027444916049,"score_gpt":0.3045037070781672,"score_spread":0.2489134326290067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}