{"id":"W4361822975","doi":"10.1158/0008-5472.c.6513538.v1","title":"Data from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; Instituto de Salud Carlos III; National Health and Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Heidelberger Stiftung Chirurgie; University of California, San Francisco; Ministero della Salute; Grantová Agentura České Republiky; California Department of Public Health; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; New York City Department of Health and Mental Hygiene; National Institute for Health and Care Research; University of Washington; Memorial Sloan-Kettering Cancer Center; Fondazione Italiana per la ricerca sulle Malattie del Pancreas; Johns Hopkins University; Ministerio de Ciencia y Tecnología; Cancer Council Victoria; Yale University; U.S. Department of Defense; Kaiser Permanente; State of Connecticut Department of Public Health; Associazione Italiana per la Ricerca sul Cancro; Medical Research Council; Pancreatic Cancer Action Network; Ministerstvo Zdravotnictví Ceské Republiky; American Cancer Society","keywords":"Expression quantitative trait loci; Genotype; Single-nucleotide polymorphism; Genome-wide association study; SNP; Biology; Genetics; Linkage disequilibrium; Pancreatic cancer; Quantitative trait locus; Allele; Genetic association; Internal medicine; Medicine; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001289273,0.0003390588,0.0004592672,0.0008998648,0.0004496576,0.0006438144,0.0004221797,0.0004274666,0.006249889],"category_scores_gemma":[0.00462188,0.0002281335,0.001276498,0.001485749,0.0002791569,0.000163928,0.000464839,0.0004348104,0.0005570531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057773,"about_ca_system_score_gemma":0.0003069098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005913714,"about_ca_topic_score_gemma":0.00517911,"domain_scores_codex":[0.9985868,0.0005677739,0.0001135378,0.0003491146,0.00027961,0.0001031976],"domain_scores_gemma":[0.9966242,0.001702715,0.000728151,0.0004425925,0.0002208683,0.000281425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001587438,0.00007639276,0.9645851,0.00007021528,0.0009634023,0.0005564024,0.0002283356,0.0003946255,0.02139808,0.0001994734,0.0008142113,0.009126286],"study_design_scores_gemma":[0.00005833892,0.0001069567,0.9957546,0.000008886775,0.0003740157,0.0005122423,0.00003893767,0.0004103224,0.001326641,0.0001651498,0.001235695,0.000008242157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9916248,0.0004819364,0.001884139,0.0003007374,0.00003116371,0.00001710757,0.004016124,0.00006125031,0.001582773],"genre_scores_gemma":[0.9961053,0.0001320736,0.0005322979,0.0001008707,0.00002846083,0.00002908279,0.00230593,0.00003673598,0.0007292175],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.006249889,"threshold_uncertainty_score":0.02090794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2447084713458428,"score_gpt":0.4410265953213957,"score_spread":0.1963181239755529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}