{"id":"W4361823456","doi":"10.1158/0008-5472.c.6514040.v1","title":"Data from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"RIKEN; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Foundation for Computational Science; Japan Agency for Medical Research and Development","keywords":"Druggability; Mutation; Carcinogenesis; In silico; Mutant; Proto-Oncogene Proteins c-ret; Cancer research; Biology; Chemistry; Genetics; Cancer; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399388,0.0003856314,0.0003683234,0.0002055501,0.0002569393,0.0003942508,0.0004569133,0.0003378496,0.001633587],"category_scores_gemma":[0.0004149529,0.0001953947,0.0004770097,0.0003190122,0.0001576998,0.0001981049,0.0001717247,0.0004465615,0.0003158672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005121641,"about_ca_system_score_gemma":0.0004280976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003814918,"about_ca_topic_score_gemma":0.006031698,"domain_scores_codex":[0.9998623,0.00001433936,0.000008978409,0.00003070471,0.00006515758,0.00001850229],"domain_scores_gemma":[0.9998839,0.00003725892,0.00002976327,0.0000170847,0.00001877612,0.00001313748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008497746,0.000297744,0.02842661,0.000429322,0.0002633555,0.0008519379,0.00009101145,0.2892817,0.6508825,0.00659764,0.003361619,0.01866679],"study_design_scores_gemma":[0.00009414145,0.0003045434,0.01601099,0.00001608124,0.0001185057,0.0003819589,0.00009652203,0.7318751,0.2433521,0.003028561,0.004678062,0.00004350335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9886143,0.0001181716,0.006710796,0.000125538,0.00002128767,0.00001528067,0.001809731,0.0004099349,0.002174791],"genre_scores_gemma":[0.9927582,0.00009795903,0.004185345,0.00003866215,0.00000258764,0.00001661199,0.002400762,0.0001032951,0.0003965915],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.003814918,"threshold_uncertainty_score":0.007585406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2629198472895612,"score_gpt":0.4038236544597567,"score_spread":0.1409038071701955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}