{"id":"W4361824681","doi":"10.1158/0008-5472.c.6513157.v1","title":"Data from <i>TET2</i> and <i>DNMT3A</i> Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Austrian Science Fund; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; ECOG-ACRIN Cancer Research Group; Memorial Sloan-Kettering Cancer Center; American College of Radiology Imaging Network; Leukemia and Lymphoma Society","keywords":"Molecular biology; Biology; DNA methylation; Cancer research; Chemistry; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122994,0.001582121,0.002149611,0.001847756,0.001559012,0.001363037,0.001159707,0.001939699,0.07036752],"category_scores_gemma":[0.001351356,0.0004964325,0.002034076,0.002663326,0.001183445,0.001225879,0.0007577231,0.005476339,0.02234969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001010672,"about_ca_system_score_gemma":0.00147521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005054845,"about_ca_topic_score_gemma":0.005311265,"domain_scores_codex":[0.9977809,0.0001511625,0.0003920231,0.0004121523,0.0007381578,0.0005256002],"domain_scores_gemma":[0.9975278,0.0005554879,0.0002358034,0.0006058998,0.0005436541,0.0005313263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02066403,0.007555286,0.009457078,0.002997608,0.001188337,0.001396655,0.0005932455,0.002328885,0.7231706,0.004257942,0.1560331,0.07035729],"study_design_scores_gemma":[0.001852536,0.00523395,0.08294759,0.0001664646,0.0006011579,0.002847658,0.0008452223,0.001257325,0.5680149,0.001439341,0.3346186,0.0001752638],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.2721679,0.005903659,0.01856785,0.005014354,0.004375266,0.001338142,0.5876453,0.003678102,0.1013095],"genre_scores_gemma":[0.3400414,0.006084609,0.01736086,0.00320631,0.0003508369,0.002679308,0.5146694,0.0009244706,0.1146828],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.07036752,"threshold_uncertainty_score":0.2354028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03645697205000999,"score_gpt":0.2975790861642553,"score_spread":0.2611221141142454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}