{"id":"W4361825050","doi":"10.1158/0008-5472.c.6512377.v1","title":"Data from Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Medical Research Council; Ministero dello Sviluppo Economico; University College London Hospitals NHS Foundation Trust; Chordoma Foundation; European Commission; Rosetrees Trust; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Fondation Leducq; Merck KGaA; National Institute for Health and Care Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Sarcoma UK; Pfizer","keywords":"Brachyury; Biology; Cancer research; Chordoma; Ectopic expression; Demethylase; H3K4me3; Demethylating agent; Epigenetics; Programmed cell death; Histone; Transcription factor; Cell biology; Cell culture; Apoptosis; Genetics; Gene expression; DNA methylation; Embryonic stem cell; Gene; Promoter; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757198,0.0004943855,0.000508094,0.000362141,0.0002492016,0.0003270601,0.0003271876,0.0003698189,0.009240627],"category_scores_gemma":[0.0001344464,0.0001593919,0.0006944573,0.0003142656,0.0002658305,0.0002202925,0.0001998684,0.001244072,0.001890241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003833048,"about_ca_system_score_gemma":0.000353456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001795467,"about_ca_topic_score_gemma":0.002459534,"domain_scores_codex":[0.9996797,0.00002080807,0.00004633706,0.00006546774,0.0001255564,0.00006209685],"domain_scores_gemma":[0.99978,0.00004503637,0.00003870267,0.00003553427,0.00004106705,0.00005956985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008981257,0.0001655345,0.000484971,0.0001974552,0.000041892,0.0001051498,0.0000215346,0.0001573105,0.9921604,0.0001639846,0.001127512,0.0044762],"study_design_scores_gemma":[0.00004182965,0.0004274676,0.00505921,0.000006902113,0.00002894119,0.0002189212,0.00003344356,0.000365301,0.9869409,0.00003438275,0.006836052,0.00000660742],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9196576,0.005672731,0.01001799,0.001123133,0.0006576398,0.0002110321,0.03572313,0.001183936,0.0257528],"genre_scores_gemma":[0.936403,0.002925982,0.00563456,0.000605043,0.00003418854,0.0002583751,0.02250086,0.0001541237,0.031484],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.009240627,"threshold_uncertainty_score":0.030913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1013495664953581,"score_gpt":0.3602522113187084,"score_spread":0.2589026448233503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}