{"id":"W4361826965","doi":"10.1158/0008-5472.c.6513498.v1","title":"Data from Acquired <i>RAD51C</i> Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma","year":2023,"lang":"en","type":"preprint","venue":"","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Council Tasmania; Cancer Council Victoria; Cancer Council South Australia; Cancer Research Institute; AstraZeneca; National Health and Medical Research Council; Entertainment Industry Foundation; Stand Up To Cancer; Medical Research Council; Peter MacCallum Foundation; AstraZeneca Australia; Medical Research and Materiel Command; Eisai; Ovarian Cancer Research Fund; Cancer Australia; National Cancer Institute; Australian Cancer Research Foundation; National Breast Cancer Foundation; Clovis Oncology; Cancer Council NSW; Ovarian Cancer Australia; Sierra Oncology; State Government of Victoria; Mayo Foundation for Medical Education and Research; National Ovarian Cancer Coalition; American Association for Cancer Research; Australian Government; Ovarian Cancer Research Fund Alliance; National Institutes of Health","keywords":"Cancer research; DNA methylation; Methylation; Gene silencing; CpG site; Biology; Molecular biology; Gene; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001123984,0.0006585496,0.001195312,0.001260779,0.001121547,0.0008219007,0.0004722486,0.0007849931,0.02360227],"category_scores_gemma":[0.0008620475,0.0002761895,0.0008661494,0.001723903,0.000572225,0.000523043,0.0005754234,0.00208755,0.004994807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005829336,"about_ca_system_score_gemma":0.0009571043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004232142,"about_ca_topic_score_gemma":0.006527847,"domain_scores_codex":[0.9985291,0.000124145,0.0002574566,0.000292306,0.0005197473,0.000277267],"domain_scores_gemma":[0.9986466,0.0002275445,0.0001694703,0.0002715291,0.0004407806,0.0002440626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009841495,0.002931431,0.03593775,0.001515528,0.0005241329,0.0008692617,0.0005562407,0.001881657,0.8538393,0.0009778943,0.04439021,0.04673515],"study_design_scores_gemma":[0.0005337569,0.004287129,0.2665381,0.000142565,0.0004401519,0.002162745,0.001473045,0.004311067,0.6154738,0.0007309077,0.1037007,0.0002060123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.6864741,0.002053495,0.01376098,0.0008053645,0.0007874262,0.001143898,0.2682914,0.001583411,0.02509993],"genre_scores_gemma":[0.7441362,0.002175328,0.01289108,0.001014136,0.00008783397,0.002911811,0.1965077,0.0005551865,0.03972085],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.02360227,"threshold_uncertainty_score":0.0789575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08580829755801006,"score_gpt":0.3277233592894588,"score_spread":0.2419150617314487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}