{"id":"W4361864049","doi":"10.1101/2023.03.30.23287124","title":"Viral and Host Mediators of Non-Suppressible HIV-1 Viremia","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; Michael Smith Health Research BC; Harvard University Center for AIDS Research; Harvard University; Frederick National Laboratory for Cancer Research; Gilead Sciences; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Viremia; Downregulation and upregulation; Virology; Biology; Viral load; Gene silencing; Interferon; CD8; Epigenetics; Gene; Viral replication; Immunology; Human immunodeficiency virus (HIV); Virus; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002576021,0.0001957958,0.0001698641,0.0002359501,0.0001504347,0.0005005231,0.000116696,0.0002055689,0.003034786],"category_scores_gemma":[0.0002038388,0.00007427437,0.0001306789,0.00009984335,0.0001868643,0.0001672464,0.0002403888,0.0003094285,0.0003457557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001405849,"about_ca_system_score_gemma":0.0001082887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001390944,"about_ca_topic_score_gemma":0.0001053163,"domain_scores_codex":[0.9998833,0.00002960707,0.000007024983,0.00002026858,0.00004030788,0.00001946069],"domain_scores_gemma":[0.999921,0.00002233769,0.0000233548,0.000008001079,0.00001014401,0.00001518089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009432196,0.00009198953,0.01933169,0.0002317536,0.00002636198,0.0003038825,0.0001224593,0.0001454006,0.9635,0.0008263598,0.0002943576,0.01418251],"study_design_scores_gemma":[0.00009956279,0.001341723,0.2099585,0.00004915825,0.00009322692,0.00287433,0.0004213234,0.002157753,0.770716,0.002305603,0.009965979,0.00001683742],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890576,0.004918227,0.002088066,0.0001509298,0.00004929802,0.00004530676,0.0006913257,0.00004168933,0.00295766],"genre_scores_gemma":[0.995948,0.0006238456,0.0008872491,0.00002727599,0.00002782011,0.000023276,0.0003227643,0.000006948312,0.002132827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003034786,"threshold_uncertainty_score":0.0101524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0178625235190609,"score_gpt":0.2795902697255963,"score_spread":0.2617277462065353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}