{"id":"W4361870177","doi":"10.1158/0008-5472.22379901","title":"Supplementary Tables 1-3, Figures 1-6 from PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A–Mediated Inactivation in Human Malignant Glioma","year":2023,"lang":"en","type":"supplementary-materials","venue":"","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Pirkanmaan Sairaanhoitopiiri; Emil Aaltosen Säätiö; Helsingin ja Uudenmaan Sairaanhoitopiiri; Damon Runyon Cancer Research Foundation","keywords":"Phosphatase; Extracellular; Glioma; Extracellular signal-regulated kinases; Kinase; Signal transduction; Protein phosphatase 2; Chemistry; Protein kinase A; Biochemistry; Cell biology; Cancer research; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001120432,0.002164783,0.001115058,0.003093922,0.001042274,0.001474138,0.002992264,0.001102922,0.7072426],"category_scores_gemma":[0.005251545,0.001027886,0.001056388,0.003493865,0.0003722092,0.001465221,0.0007676888,0.001948156,0.2831765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002462742,"about_ca_system_score_gemma":0.003201835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00512005,"about_ca_topic_score_gemma":0.01198005,"domain_scores_codex":[0.9989329,0.0001175117,0.0001215977,0.0001456881,0.0005440104,0.0001383301],"domain_scores_gemma":[0.9961883,0.001597023,0.0002279493,0.0004597081,0.001002342,0.000524736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000529127,0.0002692876,0.0003878008,0.0009700297,0.00003236638,0.0001106036,0.00001535335,0.0007871119,0.006170607,0.002735184,0.9676483,0.02034426],"study_design_scores_gemma":[0.0005321229,0.0002573351,0.005464109,0.0002416658,0.00004172516,0.0003199312,0.00005008776,0.00139928,0.02272791,0.005627117,0.9632792,0.00005945307],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0008953164,0.0005835274,0.004550086,0.0007106033,0.001126903,0.0003570711,0.9602908,0.001859826,0.02962577],"genre_scores_gemma":[0.004496748,0.0009230158,0.009246749,0.0003990624,0.0001884478,0.0007763657,0.9450088,0.0007629278,0.03819783],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.7072426,"threshold_uncertainty_score":0.4175829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164161853837843,"score_gpt":0.2440016393913676,"score_spread":0.2275854540075833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}