{"id":"W4361888704","doi":"10.1158/1078-0432.22474871","title":"Supplementary material and tables from A Biomarker-enriched, Randomized Phase II Trial of Adavosertib (AZD1775) Plus Paclitaxel and Carboplatin for Women with Platinum-sensitive <i>TP53</i>-mutant Ovarian Cancer","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre","funders":"","keywords":"Carboplatin; Paclitaxel; Biomarker; Mutant; Internal medicine; Oncology; Chemistry; Medicine; Cancer; Biochemistry; Cisplatin; Gene; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001798874,0.001739538,0.00170421,0.001651567,0.0006100825,0.001828455,0.001418191,0.001092607,0.7307644],"category_scores_gemma":[0.01998716,0.0008235505,0.001510064,0.002184431,0.0002393653,0.0008265096,0.0007222287,0.001348298,0.121799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00108481,"about_ca_system_score_gemma":0.002807043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003510716,"about_ca_topic_score_gemma":0.008246889,"domain_scores_codex":[0.9988047,0.0002633086,0.0002123107,0.000198262,0.0003730425,0.0001484215],"domain_scores_gemma":[0.988959,0.006894005,0.001120891,0.000957766,0.001233449,0.000834961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.003389562,0.0003727071,0.001015271,0.003034755,0.00051393,0.0001463494,0.0000196597,0.00132441,0.0006074377,0.00138568,0.9608454,0.02734484],"study_design_scores_gemma":[0.0334575,0.00207795,0.02269736,0.001644008,0.00125448,0.001449885,0.00008067776,0.003706255,0.002115327,0.03296881,0.8983672,0.0001805953],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.00105186,0.0005463295,0.001709656,0.000627387,0.0009278089,0.0004997207,0.9878421,0.00060144,0.00619365],"genre_scores_gemma":[0.01349073,0.001242314,0.01133835,0.002204972,0.000997195,0.003418267,0.9430686,0.001183682,0.02305593],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.7307644,"threshold_uncertainty_score":0.3840319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02585051991472063,"score_gpt":0.294971828524104,"score_spread":0.2691213086093834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}