{"id":"W4361917537","doi":"10.1158/1078-0432.22458372.v1","title":"Supplementary Tables S1-S6, Figures S1-S2 from A Phase Ib Dose-Escalation Study of the Oral Pan-PI3K Inhibitor Buparlisib (BKM120) in Combination with the Oral MEK1/2 Inhibitor Trametinib (GSK1120212) in Patients with Selected Advanced Solid Tumors","year":2023,"lang":"en","type":"supplementary-materials","venue":"","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00402797,0.001703879,0.001906556,0.002251303,0.00137901,0.00236517,0.002346624,0.001225025,0.7930243],"category_scores_gemma":[0.02789365,0.000944962,0.001608556,0.004818822,0.000371002,0.001616827,0.001044119,0.001707628,0.2129142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001645587,"about_ca_system_score_gemma":0.005341209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004000502,"about_ca_topic_score_gemma":0.01042831,"domain_scores_codex":[0.9974463,0.0005883114,0.0004579522,0.0004556972,0.0008621346,0.0001896101],"domain_scores_gemma":[0.978692,0.01126629,0.001969386,0.001891903,0.004937818,0.00124266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.001382014,0.0001641208,0.0007422693,0.003051041,0.0001310285,0.00006657641,0.00003026363,0.0007806218,0.0006538994,0.0008884023,0.9671038,0.0250059],"study_design_scores_gemma":[0.002591864,0.0008917704,0.005382446,0.00101914,0.0002478681,0.0003085274,0.00007139772,0.0008560102,0.001439846,0.005086687,0.9820363,0.00006819214],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0004684987,0.0003848564,0.001840381,0.000384063,0.0006234231,0.0008243757,0.9873428,0.0007443076,0.007387228],"genre_scores_gemma":[0.005517711,0.001458388,0.007157377,0.001815787,0.000537863,0.00481788,0.9555215,0.0009908805,0.0221827],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.7930243,"threshold_uncertainty_score":0.2952257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007497050927852877,"score_gpt":0.2597603764156305,"score_spread":0.2522633254877777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}