{"id":"W4361938797","doi":"10.1158/1078-0432.22479515.v1","title":"Supplementary Methods from Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients with <i>PIK3CA</i>-Mutant Cancers","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Genentech; Memorial Sloan-Kettering Cancer Center","keywords":"Mutant; Gene isoform; PI3K/AKT/mTOR pathway; Cancer research; Chemistry; Internal medicine; Biology; Medicine; Apoptosis; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002061601,0.001582406,0.001560762,0.0007771198,0.0004811771,0.001393464,0.001471991,0.00143706,0.5092736],"category_scores_gemma":[0.009984716,0.001181952,0.002479747,0.0007386123,0.0002477208,0.000867218,0.000439244,0.002110579,0.05640985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008911807,"about_ca_system_score_gemma":0.002134388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002352269,"about_ca_topic_score_gemma":0.005908623,"domain_scores_codex":[0.9992707,0.0002535469,0.0001096252,0.0001229968,0.0001650593,0.00007799624],"domain_scores_gemma":[0.9959942,0.002219652,0.0004105877,0.0004156336,0.0004855148,0.0004743807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01473668,0.0007316593,0.001277258,0.004087916,0.001143123,0.0002252103,0.00003063609,0.001459712,0.001359911,0.002341362,0.9171579,0.05544862],"study_design_scores_gemma":[0.1791876,0.006140515,0.0210664,0.002850566,0.002236539,0.00194912,0.00007498438,0.004781447,0.004366505,0.02076611,0.7563784,0.0002018253],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"methods","genre_scores_codex":[0.006134785,0.004759006,0.01370224,0.005805316,0.006826701,0.007349753,0.9356587,0.002023417,0.01774001],"genre_scores_gemma":[0.04623853,0.008012513,0.06011257,0.01882048,0.006209933,0.05460028,0.7351679,0.0026002,0.06823766],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5092736,"threshold_uncertainty_score":0.6999617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02429356914993505,"score_gpt":0.3817978954849942,"score_spread":0.3575043263350591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}