{"id":"W4361943496","doi":"10.1158/1078-0432.c.6518080","title":"Data from High Frequency of Hereditary Colorectal Cancer in Newfoundland Likely Involves Novel Susceptibility Genes","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"MLH1; MSH6; MSH2; Colorectal cancer; Microsatellite instability; Lynch syndrome; Population; Medicine; Cancer; Genetics; Proband; DNA mismatch repair; Mutation; Biology; Internal medicine; Cancer research; Gene; Microsatellite; Allele","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004467602,0.0001883893,0.0002381928,0.00141909,0.0008149329,0.0004049817,0.0003785845,0.0002204377,0.005162098],"category_scores_gemma":[0.001793887,0.0001515089,0.0002807351,0.001640318,0.0003744656,0.0002032356,0.0004402018,0.0002550927,0.0003645586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00270551,"about_ca_system_score_gemma":0.00131487,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.5479056,"about_ca_topic_score_gemma":0.7329962,"domain_scores_codex":[0.9994738,0.00008390981,0.00004638215,0.0001396652,0.0001145881,0.0001417873],"domain_scores_gemma":[0.9969658,0.0004832208,0.001020091,0.0003298738,0.0007303499,0.0004706878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007840266,0.00001147351,0.9954156,0.00001351981,0.00003140418,0.0001968039,0.00007514749,0.0000490585,0.0006268282,0.00003022649,0.00104307,0.002428486],"study_design_scores_gemma":[0.000002923218,0.0000107015,0.998985,0.000003835425,0.00001064925,0.0002048474,0.00006118231,0.00002570454,0.00006939327,0.000004062297,0.0006199629,0.000001675057],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9870003,0.0004815462,0.0003036821,0.0003062944,0.00001704644,0.00001877592,0.006310042,0.00002439658,0.005537931],"genre_scores_gemma":[0.994014,0.000219221,0.000227591,0.0001362675,0.00001446772,0.00002041159,0.003748417,0.000008058782,0.001611635],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.4520944,"threshold_uncertainty_score":0.9095137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110699501703183,"score_gpt":0.3432814940687509,"score_spread":0.2322115438984325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}