{"id":"W4361946972","doi":"10.1158/1078-0432.c.6528495","title":"Data from Comprehensive Transcriptomic Profiling Identifies Breast Cancer Patients Who May Be Spared Adjuvant Systemic Therapy","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Decipher Biosciences (Canada); Genome British Columbia","funders":"Gunnar Nilssons Cancerstiftelse; Lunds Universitet; Cancerfonden","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Adjuvant therapy; Cohort; Radiation therapy; Adjuvant; Subgroup analysis; Endocrine system; Systemic therapy; Chemotherapy; Cancer; Meta-analysis; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004214767,0.0001757414,0.0005616857,0.0006019131,0.0001817032,0.0004126585,0.0001712505,0.0002472131,0.001179266],"category_scores_gemma":[0.001084315,0.00007990157,0.0004155132,0.0009926287,0.0001458125,0.0001719392,0.0003764717,0.0002035218,0.0003033445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726757,"about_ca_system_score_gemma":0.0002670624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005916649,"about_ca_topic_score_gemma":0.00164617,"domain_scores_codex":[0.9996817,0.00005972412,0.00003738652,0.0001092037,0.00006866604,0.00004330275],"domain_scores_gemma":[0.999286,0.0002166331,0.0002457288,0.00008185403,0.00008429528,0.00008542161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00536663,0.0001560969,0.8513773,0.0003786463,0.0004544005,0.0003642106,0.0001707809,0.001224098,0.09451638,0.0001992713,0.002488887,0.04330323],"study_design_scores_gemma":[0.00006158389,0.0004685259,0.9900592,0.00002438031,0.0002355359,0.0005854083,0.0001450475,0.001157647,0.004369612,0.000175971,0.002702113,0.00001494506],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879302,0.001130487,0.0008985606,0.0001385089,0.00000967095,0.00002451196,0.008869131,0.00002511065,0.0009738337],"genre_scores_gemma":[0.9809487,0.000433348,0.001002996,0.0001150633,0.00002235502,0.00005157407,0.01705694,0.000009880874,0.000359211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001179266,"threshold_uncertainty_score":0.003945053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0684237773569893,"score_gpt":0.3094256353098526,"score_spread":0.2410018579528633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}