{"id":"W4361947518","doi":"10.1158/1078-0432.c.6530985","title":"Data from Safety and Antitumor Activity of α-PD-L1 Antibody as Monotherapy or in Combination with α-TIM-3 Antibody in Patients with Microsatellite Instability–High/Mismatch Repair–Deficient Tumors","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Eli Lilly and Company","keywords":"Microsatellite instability; Medicine; Internal medicine; Tolerability; Antibody; Refractory (planetary science); Adverse effect; Gastroenterology; Combination therapy; Oncology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001590871,0.0005693213,0.001226805,0.0002623216,0.0002968286,0.000732392,0.0004458838,0.0007256181,0.003704673],"category_scores_gemma":[0.001324149,0.0002668834,0.00127077,0.0005027223,0.0004807189,0.0006119664,0.0001971937,0.001629504,0.0009881435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007297341,"about_ca_system_score_gemma":0.0007898554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005318003,"about_ca_topic_score_gemma":0.001379376,"domain_scores_codex":[0.9994366,0.0002850789,0.00007087768,0.0000726368,0.00006485495,0.000070055],"domain_scores_gemma":[0.998349,0.000510594,0.0004212623,0.0001757192,0.0001030969,0.0004404287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6686409,0.01013042,0.02092112,0.001988094,0.002065666,0.0005772182,0.0002433488,0.00258654,0.0645856,0.0004172018,0.01228895,0.215555],"study_design_scores_gemma":[0.3197307,0.5415537,0.08016987,0.0005279275,0.00323903,0.002100718,0.0001522106,0.001894147,0.02262722,0.0005923104,0.02733474,0.00007743443],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711793,0.01082759,0.001119796,0.001000321,0.0001900972,0.0009802342,0.00411058,0.0001265869,0.01046543],"genre_scores_gemma":[0.9889656,0.002649359,0.0005827167,0.001196691,0.0001395732,0.0007139709,0.003845406,0.00003636161,0.001870328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003704673,"threshold_uncertainty_score":0.01239336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03123550594198082,"score_gpt":0.3194895697172722,"score_spread":0.2882540637752914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}