{"id":"W4361953411","doi":"10.1158/1078-0432.c.6529767.v1","title":"Data from Phase Ib Dose-escalation/Expansion Trial of Ribociclib in Combination With Everolimus and Exemestane in Postmenopausal Women with HR<sup>+</sup>, HER2<sup>−</sup> Advanced Breast Cancer","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Everolimus; Exemestane; Internal medicine; Tolerability; Breast cancer; Adverse effect; Oncology; Cancer; Gastroenterology; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001545841,0.002116742,0.003843127,0.00152161,0.0002411445,0.0001790728,0.001387769,0.001134886,0.0009710168],"category_scores_gemma":[0.0002708484,0.001809256,0.0001629961,0.002032319,0.0008692048,0.001770005,0.001572396,0.0020284,0.0000309016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002670948,"about_ca_system_score_gemma":0.002208966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003492512,"about_ca_topic_score_gemma":0.01025442,"domain_scores_codex":[0.9879286,0.0006587225,0.002919679,0.003851444,0.002746426,0.001895167],"domain_scores_gemma":[0.9918656,0.0008032678,0.001767546,0.003687601,0.001040826,0.0008351075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6724428,0.01182952,0.01278702,0.002806608,0.003628865,0.001426567,0.01365007,0.03811371,0.04830356,0.0004459085,0.001004654,0.1935607],"study_design_scores_gemma":[0.6697718,0.0182488,0.2086495,0.0152101,0.002239685,0.0005832768,0.005764853,0.05842825,0.001821773,0.00493348,0.007846504,0.006502015],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753703,0.002203373,0.002310017,0.00279886,0.0006375292,0.007830229,0.007916881,0.0006006919,0.0003321063],"genre_scores_gemma":[0.9748542,0.002518013,0.007313019,0.0004419709,0.0008010177,0.001962447,0.01006943,0.000617045,0.001422875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1958625,"threshold_uncertainty_score":0.9999422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0286051356831239,"score_gpt":0.3199529618484541,"score_spread":0.2913478261653302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}