{"id":"W4361953581","doi":"10.1158/1078-0432.c.6530073.v1","title":"Data from Expanded Low Allele Frequency <i>RAS</i> and <i>BRAF</i> V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; University of British Columbia","funders":"National Institutes of Health; American Society of Clinical Oncology","keywords":"Cetuximab; KRAS; Neuroblastoma RAS viral oncogene homolog; Colorectal cancer; Medicine; Internal medicine; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002352956,0.0006892164,0.00138748,0.0002009919,0.0002682137,0.0008454947,0.0003808418,0.0006662151,0.004950867],"category_scores_gemma":[0.003198025,0.000273929,0.00138578,0.0004322677,0.0004536668,0.0006678097,0.000304314,0.00154088,0.0007194767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007847961,"about_ca_system_score_gemma":0.0009043037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007804995,"about_ca_topic_score_gemma":0.00302758,"domain_scores_codex":[0.9985655,0.0006813901,0.0001312987,0.000287117,0.000190942,0.0001437906],"domain_scores_gemma":[0.9960696,0.001501683,0.001084289,0.0004415371,0.0003470965,0.0005557627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8848258,0.001848906,0.03730314,0.001202168,0.00497448,0.000169056,0.00009119158,0.001674186,0.01252116,0.0003135237,0.01143859,0.04363769],"study_design_scores_gemma":[0.5874256,0.1303293,0.2138788,0.0003724811,0.01813328,0.001087164,0.0001185108,0.002682549,0.01876216,0.0009324678,0.02614571,0.0001319949],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.973081,0.004933982,0.0009879621,0.001183183,0.0001951448,0.001363107,0.01097136,0.0000717147,0.007212661],"genre_scores_gemma":[0.9796434,0.001305394,0.000889522,0.0009392698,0.0001262974,0.001248395,0.01210758,0.00004479508,0.003695489],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.004950867,"threshold_uncertainty_score":0.01656234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07705334633752861,"score_gpt":0.3489894885960454,"score_spread":0.2719361422585168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}