{"id":"W4361953659","doi":"10.1158/1078-0432.c.6530237.v1","title":"Data from Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients with &lt;i&gt;PIK3CA&lt;/i&gt;-Mutant Cancers","year":2023,"lang":"en","type":"preprint","venue":"","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Genentech; Memorial Sloan-Kettering Cancer Center","keywords":"PTEN; Mutant; P110α; PI3K/AKT/mTOR pathway; Cancer; Mutation; Cancer research; Biology; Molecular biology; Medicine; Internal medicine; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001991507,0.00107933,0.002081957,0.000376633,0.000408104,0.001187543,0.0006937195,0.0007509109,0.003222772],"category_scores_gemma":[0.00146688,0.0005277543,0.001629915,0.0008083686,0.0004762621,0.001248796,0.0004194929,0.001475982,0.000721648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001144033,"about_ca_system_score_gemma":0.001396063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009913566,"about_ca_topic_score_gemma":0.002989894,"domain_scores_codex":[0.9993404,0.0002464688,0.00007345981,0.0001552107,0.00008539857,0.00009898937],"domain_scores_gemma":[0.998678,0.0002160183,0.000403655,0.0001656944,0.0001447361,0.0003917932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7686828,0.006992864,0.07733625,0.0009765573,0.00546041,0.0002871441,0.0001999451,0.004162118,0.03718334,0.0006160424,0.01513857,0.08296403],"study_design_scores_gemma":[0.4870161,0.2740369,0.1925636,0.0002015201,0.008003276,0.001308666,0.0002736453,0.003613491,0.01343965,0.001479729,0.01790644,0.0001570975],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9782834,0.002090422,0.001004814,0.000530271,0.0001103491,0.001327453,0.01270984,0.000083575,0.003859951],"genre_scores_gemma":[0.9681954,0.001640966,0.001842952,0.0009063748,0.0001029451,0.001955242,0.02337894,0.00005360739,0.001923463],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.003222772,"threshold_uncertainty_score":0.01078123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03167037357877012,"score_gpt":0.3085426275903196,"score_spread":0.2768722540115495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}