{"id":"W4361954047","doi":"10.1158/1535-7163.c.6531972.v1","title":"Data from Drug ratio–dependent antitumor activity of irinotecan and cisplatin combinations &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Irinotecan; Cisplatin; In vivo; Pharmacology; Chemistry; In vitro; Drug; Medicine; Chemotherapy; Cancer; Biology; Internal medicine; Biochemistry; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005609213,0.0007320289,0.0005824535,0.0006691725,0.0001646088,0.0002496761,0.0003343207,0.0004227887,0.004609705],"category_scores_gemma":[0.0004681819,0.0002363955,0.0004731466,0.0007233673,0.000307866,0.000358935,0.0001902037,0.0009236631,0.0009564884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240802,"about_ca_system_score_gemma":0.0003135979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009699594,"about_ca_topic_score_gemma":0.001420434,"domain_scores_codex":[0.9993617,0.0002079744,0.0000919802,0.0001110615,0.0001661616,0.00006109737],"domain_scores_gemma":[0.9992166,0.0003065085,0.0001177896,0.0001238471,0.0001448495,0.00009047473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100886,0.0004744274,0.0005888619,0.000163441,0.00004823125,0.00006443851,0.00005998099,0.0005979676,0.9891789,0.000099381,0.0004614228,0.007162154],"study_design_scores_gemma":[0.00004316639,0.002448642,0.003037995,0.000005694576,0.00004423589,0.0001708239,0.00002971182,0.0007561058,0.9913346,0.00002904631,0.002089426,0.00001064595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9699447,0.006127023,0.009511641,0.0002006782,0.00009452771,0.0003168035,0.004287329,0.0003909942,0.009126282],"genre_scores_gemma":[0.9781923,0.002719582,0.006727688,0.0001691303,0.00002643562,0.0004004052,0.005283734,0.00009472584,0.006386015],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.004609705,"threshold_uncertainty_score":0.01542097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03036297927178904,"score_gpt":0.2813449480662373,"score_spread":0.2509819687944483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}