{"id":"W4361954064","doi":"10.1158/1535-7163.c.6531699.v1","title":"Data from PIM Kinase Inhibitors Downregulate STAT3<sup>Tyr705</sup> Phosphorylation","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Natural Science Foundation of China; Prostate Cancer Canada","keywords":"Kinase; Molecular biology; Biology; Gene knockdown; Cell growth; Cell culture; Cancer research; Apoptosis; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0008491536,0.0009205991,0.001321639,0.000381724,0.000179,0.000222316,0.000944608,0.0008949186,0.006672461],"category_scores_gemma":[0.0001201502,0.0008318241,0.0003742012,0.0004367569,0.0001223362,0.0002689933,0.002165386,0.001148978,0.001048318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004832601,"about_ca_system_score_gemma":0.0007361996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004773971,"about_ca_topic_score_gemma":0.002134981,"domain_scores_codex":[0.9943978,0.0001163883,0.001177295,0.002269923,0.001254894,0.0007837485],"domain_scores_gemma":[0.9942366,0.0001842248,0.0004852274,0.004292834,0.000282764,0.0005183042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005403406,0.001643322,0.0008939864,0.001596897,0.005798556,0.001486941,0.004295449,0.005795895,0.1322433,0.00950151,0.661911,0.1694298],"study_design_scores_gemma":[0.01529284,0.001165688,0.01194895,0.004530497,0.002816563,0.00004197318,0.001021076,0.1111561,0.06715105,0.06817846,0.7121818,0.004514967],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8754042,0.01415345,0.03769957,0.01502339,0.01438762,0.008730231,0.02130593,0.004308999,0.008986647],"genre_scores_gemma":[0.7989963,0.01244738,0.02484099,0.003525657,0.0105192,0.0006129848,0.08369323,0.001166356,0.06419791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1649148,"threshold_uncertainty_score":0.9997295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05981305426137706,"score_gpt":0.3089182844197401,"score_spread":0.249105230158363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}