{"id":"W4361954339","doi":"10.1158/1078-0432.c.6532970.v1","title":"Data from Detection of <i>BRCA1</i>, <i>BRCA2</i>, and <i>ATM</i> Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Astellas Pharma; AstraZeneca; Ipsen; Pfizer","keywords":"Medicine; Cancer; Concordance; Internal medicine; Cancer research; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001009779,0.0002164697,0.0002704578,0.000476423,0.0001676825,0.0003965404,0.0002472885,0.0002354093,0.001805765],"category_scores_gemma":[0.002678648,0.0001312529,0.000267529,0.00039,0.0002291711,0.0002194111,0.000291663,0.0003509344,0.0002715937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003026552,"about_ca_system_score_gemma":0.0003831197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009381562,"about_ca_topic_score_gemma":0.00142816,"domain_scores_codex":[0.9993761,0.0001405688,0.00008558948,0.0001811857,0.0001602487,0.00005636999],"domain_scores_gemma":[0.9966767,0.001151767,0.0009638747,0.0004357235,0.0003570359,0.0004149201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01229539,0.000331145,0.9322354,0.0001393486,0.0001623006,0.0002548041,0.0001614122,0.0008134376,0.01925824,0.0001208003,0.001420929,0.03280692],"study_design_scores_gemma":[0.0007355243,0.007678855,0.9672994,0.00003130863,0.0003072485,0.001937094,0.0001013225,0.0007846134,0.01681806,0.0000966897,0.004182833,0.00002697586],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9934082,0.0003045399,0.0004691514,0.00003895324,0.000004904011,0.00005483306,0.004060654,0.00002963477,0.001629102],"genre_scores_gemma":[0.9943277,0.00008123316,0.0003730302,0.0000839011,0.000008032371,0.00003897387,0.004804417,0.000007847312,0.0002748418],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.001805765,"threshold_uncertainty_score":0.006040871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780467133344849,"score_gpt":0.2576853709334427,"score_spread":0.2398806995999943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}