{"id":"W4361954371","doi":"10.1158/1078-0432.c.6532884.v1","title":"Data from Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and <i>BRCA1, BRCA2</i>, or <i>ATM</i> Alterations Identified by Testing Circulating Tumor DNA","year":2023,"lang":"en","type":"preprint","venue":"","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Juravinski Cancer Centre","funders":"AstraZeneca","keywords":"Olaparib; Medicine; Enzalutamide; Internal medicine; Cohort; Hazard ratio; Prostate cancer; Oncology; Progression-free survival; Population; Cancer; Gastroenterology; Overall survival; Poly ADP ribose polymerase; Confidence interval; Gene; Biology; Genetics; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009418215,0.0001955494,0.0004471197,0.0004982406,0.0001276046,0.0004739675,0.0002525322,0.0002025792,0.001809937],"category_scores_gemma":[0.002087523,0.0001023404,0.0005602006,0.0007667891,0.0001653553,0.0003283481,0.0002646644,0.0004162938,0.0002418896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000353727,"about_ca_system_score_gemma":0.0004334016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000827654,"about_ca_topic_score_gemma":0.002169272,"domain_scores_codex":[0.9993864,0.0001905103,0.0001077591,0.0001251284,0.0001429409,0.00004717215],"domain_scores_gemma":[0.9967321,0.001431268,0.001002691,0.0002712922,0.0001677565,0.0003948979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08135673,0.0008017533,0.7816016,0.001073702,0.00302341,0.0005103328,0.0002463574,0.003617218,0.01062008,0.0004696107,0.004746873,0.1119324],"study_design_scores_gemma":[0.004915657,0.01231657,0.9663208,0.0001545147,0.001562284,0.001915034,0.0001371667,0.0008726488,0.002656281,0.0002879678,0.008816824,0.00004412046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9809604,0.003720849,0.0003452013,0.0001255747,0.00001483815,0.00007728313,0.01149287,0.00002038544,0.003242659],"genre_scores_gemma":[0.9925921,0.0004489867,0.0001252067,0.0001143852,0.00001849371,0.00004115154,0.006323946,0.000005189092,0.0003306548],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.001809937,"threshold_uncertainty_score":0.006054819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08377876986514131,"score_gpt":0.3297492467324734,"score_spread":0.2459704768673321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}