{"id":"W4361957761","doi":"10.1158/1078-0432.c.6529898.v1","title":"Data from Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Veterinary Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Center for Advancing Translational Sciences; Ohio State University; Virginia-Maryland College of Veterinary Medicine; Cancer Center, University of Colorado; University of California, Davis; National Cancer Institute; National Institutes of Health","keywords":"Carboplatin; Medicine; Osteosarcoma; Sirolimus; Internal medicine; Adverse effect; Confidence interval; Clinical endpoint; Clinical trial; Amputation; Randomized controlled trial; Oncology; Adjuvant therapy; Randomization; Chemotherapy; Surgery; Urology; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005819348,0.0007117075,0.00598664,0.0007271822,0.0000694534,0.0000480027,0.001498973,0.0006685163,0.0003009967],"category_scores_gemma":[0.00430664,0.0004586963,0.0009350248,0.000261659,0.000568388,0.0001420269,0.00319585,0.001558002,0.000009454061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004876546,"about_ca_system_score_gemma":0.001368462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002366609,"about_ca_topic_score_gemma":0.00119084,"domain_scores_codex":[0.9925619,0.0009839105,0.002515734,0.001887768,0.001301906,0.0007488328],"domain_scores_gemma":[0.9910008,0.004024916,0.001019777,0.003087351,0.0006722995,0.0001947957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9684547,0.0006586164,0.01211958,0.00230082,0.001556528,0.0004457949,0.001204038,0.000006091854,0.01035394,0.00002635024,0.00009061375,0.002782922],"study_design_scores_gemma":[0.978483,0.008114744,0.003658985,0.0009685102,0.0006069519,0.00003347571,0.001027535,0.001236817,0.003364048,0.001791729,0.0002122522,0.0005019589],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476066,0.001004464,0.00114531,0.002029808,0.002057508,0.03168262,0.01398048,0.0001778028,0.0003154453],"genre_scores_gemma":[0.9723153,0.001105327,0.01758442,0.00006764888,0.0005345548,0.003266061,0.003912663,0.0001969896,0.001017054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02841656,"threshold_uncertainty_score":0.9997865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027427063852695,"score_gpt":0.418270981894778,"score_spread":0.3155282755095085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}