{"id":"W4361958092","doi":"10.1158/1078-0432.c.6530916.v1","title":"Data from Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Fundamental Research Funds for the Central Universities; East China Normal University; China Postdoctoral Science Foundation; Chinese Academy of Sciences; Government of Jiangxi Province; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Cancer research; Immune system; Prostate cancer; Immunotherapy; Tumor microenvironment; CD8; T cell; Cancer immunotherapy; Chemokine; Cytotoxic T cell; In vivo; Medicine; Chemistry; Immunology; Cancer; Biology; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306435,0.000275687,0.0003660453,0.0002541588,0.0001456808,0.0003362357,0.000163662,0.0002586771,0.002461395],"category_scores_gemma":[0.0001485106,0.0001148065,0.0002975502,0.0002389656,0.0002000152,0.0001836385,0.0001427793,0.0006971193,0.0006130689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854256,"about_ca_system_score_gemma":0.000164927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002751109,"about_ca_topic_score_gemma":0.0004407188,"domain_scores_codex":[0.9998673,0.00001254636,0.00001296122,0.00003754512,0.00004788328,0.00002167848],"domain_scores_gemma":[0.9998788,0.00003226042,0.0000241882,0.0000196825,0.00002565957,0.00001941265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001477726,0.0000218297,0.0005049372,0.00004226481,0.00001163619,0.00002872186,0.00000659773,0.0002083997,0.9965494,0.00003843688,0.0001466893,0.00229321],"study_design_scores_gemma":[0.00001717811,0.0002890283,0.01127366,0.000003215315,0.00003600356,0.000148379,0.00002696753,0.002995495,0.9831021,0.0000812877,0.002019827,0.000006758181],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9628962,0.001351146,0.02541452,0.0002619712,0.00008502131,0.00006123528,0.007353243,0.0004336598,0.002142966],"genre_scores_gemma":[0.97227,0.001202615,0.0144165,0.0002406907,0.00002947372,0.0001543055,0.007319416,0.0001006539,0.004266547],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.002461395,"threshold_uncertainty_score":0.008234203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09603129604657247,"score_gpt":0.3519024830105837,"score_spread":0.2558711869640113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}