{"id":"W4361958343","doi":"10.1158/1078-0432.c.6530442.v1","title":"Data from Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Oncolytic virus; Oncolytic adenovirus; Cancer research; In vivo; Biology; Adenoviridae; Cell culture; Immune system; Molecular biology; Immunology; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004316696,0.0006203637,0.0004742613,0.0004092981,0.000276947,0.000509166,0.0003035757,0.0004565076,0.003521824],"category_scores_gemma":[0.0001865741,0.0001769043,0.0006024044,0.0002768093,0.0003622883,0.0004661337,0.0001523168,0.001733923,0.001250355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004966519,"about_ca_system_score_gemma":0.0006034375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144068,"about_ca_topic_score_gemma":0.001834758,"domain_scores_codex":[0.9996518,0.0000445934,0.00006494908,0.0000709813,0.0001089544,0.00005879765],"domain_scores_gemma":[0.999699,0.00004560546,0.0000703443,0.00005502606,0.00005532166,0.00007478278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002234686,0.0005270034,0.001038599,0.0003570259,0.00004614858,0.0001386677,0.00005894168,0.000428445,0.9864175,0.0002547112,0.001773255,0.006725008],"study_design_scores_gemma":[0.000116339,0.002108659,0.004819979,0.000020072,0.0000677355,0.0003767929,0.00009401658,0.0007124643,0.9849454,0.00008065197,0.006644666,0.00001309919],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9606004,0.003338527,0.007745045,0.0009475803,0.0003816063,0.0002413604,0.01825195,0.0004922968,0.008001372],"genre_scores_gemma":[0.9546497,0.00350148,0.008774667,0.0006974597,0.00006160878,0.0005249071,0.01407263,0.0001615668,0.0175559],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.003521824,"threshold_uncertainty_score":0.01178169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09565028463777982,"score_gpt":0.3357250818658512,"score_spread":0.2400747972280714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}