{"id":"W4361958415","doi":"10.1158/1078-0432.c.6531065.v1","title":"Data from Natural History and Characteristics of <i>ERBB2</i>-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy; National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; Unicancer; Vanderbilt University; Institut Gustave-Roussy; Puma Biotechnology; Princess Margaret Cancer Foundation; Memorial Sloan-Kettering Cancer Center; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; American Association for Cancer Research","keywords":"Breast cancer; Cancer; Medicine; Internal medicine; Metastatic breast cancer; Oncology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005411351,0.00118684,0.002772471,0.0004499903,0.0002054626,0.00005477096,0.0006799927,0.0003525231,0.0004553226],"category_scores_gemma":[0.0003839744,0.001016689,0.0002540065,0.000340723,0.0008810585,0.0004153956,0.001336152,0.001516953,0.0000239477],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004122581,"about_ca_system_score_gemma":0.002484946,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01690444,"about_ca_topic_score_gemma":0.00822542,"domain_scores_codex":[0.9939013,0.0004556935,0.001423796,0.002444471,0.001118369,0.0006563463],"domain_scores_gemma":[0.9947594,0.0005540738,0.001283528,0.001929317,0.001170344,0.0003033189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.07252108,0.01504723,0.07511255,0.001870078,0.1401382,0.03266679,0.04598908,0.0004377499,0.5063272,0.0003730445,0.01295651,0.09656048],"study_design_scores_gemma":[0.02025528,0.0006540019,0.9499869,0.001343255,0.00752016,0.0008921853,0.001532744,0.01466909,0.0001908046,0.0001494793,0.00125807,0.001547987],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6877077,0.03113494,0.007491333,0.0004573483,0.00262147,0.006293043,0.2637654,0.0004909884,0.00003784787],"genre_scores_gemma":[0.971014,0.001454173,0.01306118,0.0001696981,0.0008792206,0.0006441068,0.01187302,0.0002013484,0.0007032417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8748744,"threshold_uncertainty_score":0.9997004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04720821073975694,"score_gpt":0.3136126797953802,"score_spread":0.2664044690556232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}