{"id":"W4361958415","doi":"10.1158/1078-0432.c.6531065.v1","title":"Data from Natural History and Characteristics of <i>ERBB2</i>-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy; National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; Unicancer; Vanderbilt University; Institut Gustave-Roussy; Puma Biotechnology; Princess Margaret Cancer Foundation; Memorial Sloan-Kettering Cancer Center; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; American Association for Cancer Research","keywords":"Breast cancer; Cancer; Medicine; Internal medicine; Metastatic breast cancer; Oncology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007143721,0.0002717838,0.0003515363,0.001408065,0.0003389969,0.0004142502,0.0003745017,0.0002826683,0.00190691],"category_scores_gemma":[0.001534298,0.0004149379,0.0002660955,0.001315104,0.0003396521,0.0003532474,0.0003365436,0.0002423017,0.0004879085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004330969,"about_ca_system_score_gemma":0.0003542093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00443812,"about_ca_topic_score_gemma":0.005159141,"domain_scores_codex":[0.9992724,0.0001632592,0.00009519131,0.0002486402,0.0001456265,0.00007489973],"domain_scores_gemma":[0.998676,0.0002699098,0.0005031933,0.0002792454,0.0001143821,0.0001572148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002864417,0.00006344375,0.9962484,0.00002066824,0.00005504513,0.0003990568,0.00007014309,0.00004641272,0.0009461041,0.00002429406,0.0002858062,0.001554033],"study_design_scores_gemma":[0.00005381225,0.0002113938,0.9965823,0.000009213674,0.00005602808,0.001628754,0.0001116344,0.0001269905,0.0003522673,0.00002085798,0.000837739,0.000008848729],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9967525,0.000183851,0.0001979066,0.00001350464,0.000002910295,0.00004997838,0.00225591,0.000006215435,0.0005373203],"genre_scores_gemma":[0.995979,0.0001084283,0.000168519,0.00002621337,0.00001097515,0.00008322515,0.003381992,0.000006391402,0.0002352856],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.00443812,"threshold_uncertainty_score":0.008824587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04720821073975694,"score_gpt":0.3136126797953802,"score_spread":0.2664044690556232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}