{"id":"W4361961028","doi":"10.1158/1078-0432.c.6518824","title":"Data from Tumor Growth Inhibition by Olaparib in <i>BRCA2</i> Germline-Mutated Patient-Derived Ovarian Cancer Tissue Xenografts","year":2023,"lang":"en","type":"preprint","venue":"","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Olaparib; PARP inhibitor; Cancer research; Carboplatin; Synthetic lethality; Ovarian cancer; Serous fluid; Cancer; Medicine; Poly ADP ribose polymerase; Biology; DNA repair; Cisplatin; Internal medicine; Chemotherapy; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311731,0.0005562818,0.000509364,0.0004233253,0.0002729922,0.0003789203,0.0003197384,0.0005562424,0.006384493],"category_scores_gemma":[0.0002392419,0.000166895,0.0004490365,0.000456426,0.0002899789,0.0003185226,0.0001641866,0.001686328,0.001577033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004585274,"about_ca_system_score_gemma":0.0003569518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002383739,"about_ca_topic_score_gemma":0.002107851,"domain_scores_codex":[0.9996256,0.00006967603,0.00005686613,0.00007401882,0.0001184676,0.00005537112],"domain_scores_gemma":[0.9995416,0.0001411113,0.00006111717,0.00007883343,0.00005027688,0.0001270009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004684259,0.001757577,0.002350216,0.0002376405,0.00008646215,0.0005300193,0.0001285125,0.0009849246,0.9745671,0.0005613581,0.005122139,0.00898969],"study_design_scores_gemma":[0.0004140171,0.005081982,0.0160563,0.00001733685,0.00008792474,0.001817219,0.0001478819,0.002435998,0.9583105,0.0001463863,0.01546151,0.00002296994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9518005,0.002143624,0.005336626,0.0005992816,0.0001861165,0.0002896018,0.02516974,0.0007216673,0.01375287],"genre_scores_gemma":[0.9586542,0.001383547,0.004474311,0.0003592405,0.00002410197,0.0004466937,0.02320539,0.000178066,0.0112745],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.006384493,"threshold_uncertainty_score":0.02135825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05379661990637228,"score_gpt":0.3274010365602044,"score_spread":0.2736044166538321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}