{"id":"W4362422890","doi":"10.1101/2023.03.29.534844","title":"Similar deamination activity but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Deamination; In vitro; Biology; Mutagenesis; Enzyme; Biochemistry; Cell; Cell culture; Molecular biology; Chemistry; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744056,0.0002287571,0.0002204522,0.0002380775,0.000191743,0.0003206796,0.0001279085,0.0003197333,0.0009465597],"category_scores_gemma":[0.0001804766,0.0001425983,0.0002903291,0.0002839139,0.000147034,0.0001457912,0.0001639746,0.0005677644,0.0004601408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264528,"about_ca_system_score_gemma":0.0001577133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002347831,"about_ca_topic_score_gemma":0.002062857,"domain_scores_codex":[0.9997266,0.00004487978,0.00003273208,0.00005204627,0.00008826148,0.00005532398],"domain_scores_gemma":[0.9997523,0.00005971148,0.00003216493,0.00004981616,0.00007301805,0.0000328868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003264323,0.00001070689,0.0002781272,0.00001526126,0.000003316154,0.00002993747,0.00002210893,0.0000139803,0.9991661,0.00001808137,0.00001627579,0.0003935007],"study_design_scores_gemma":[0.000004863979,0.0002005112,0.01411456,0.000004076249,0.00001582861,0.0003510557,0.0001230026,0.0003745935,0.9830332,0.0000302526,0.001741497,0.000006366061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923448,0.001244524,0.00331796,0.00008399172,0.00003167027,0.00004371506,0.001091687,0.00008730559,0.001754376],"genre_scores_gemma":[0.9897821,0.0006090663,0.003282888,0.00007754527,0.000006110149,0.00007091984,0.002048131,0.00002489084,0.004098465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002347831,"threshold_uncertainty_score":0.004668295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078741469052229,"score_gpt":0.2461514165008514,"score_spread":0.2353640018103291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}