{"id":"W4362433139","doi":"10.1158/1078-0432.22464330","title":"Supplemental Data from Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"","keywords":"Druggability; Tamoxifen; Breast cancer; Cancer research; Oncology; Medicine; Cancer; Internal medicine; Computational biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002615449,0.0002279735,0.0002685034,0.00007393266,0.00005887789,0.00003220761,0.000208715,0.0003196262,0.00006876222],"category_scores_gemma":[0.00006418148,0.0002337857,0.00007827155,0.00009527487,0.00004630491,0.00002397356,0.0006932889,0.0001431348,0.000001288593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001377043,"about_ca_system_score_gemma":0.0001752253,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007482986,"about_ca_topic_score_gemma":0.009968044,"domain_scores_codex":[0.9981663,0.00004955939,0.0004776628,0.0008977524,0.0002066881,0.0002020294],"domain_scores_gemma":[0.9986467,0.00004989799,0.000375623,0.0007302591,0.0001529665,0.00004456122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008781534,0.0001758827,0.002310529,0.00009933767,0.0001356662,7.921626e-7,0.0001506389,0.0001857706,0.9544774,0.00002468689,0.04131409,0.0002470164],"study_design_scores_gemma":[0.002538922,0.00004347955,0.03722182,0.0006409634,0.00005040256,0.000001468415,0.0002933588,0.001988655,0.9508656,0.0005358751,0.005357565,0.000461881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8925914,0.0002380232,0.02460786,0.0008867019,0.0005714798,0.001237093,0.07963323,0.00002734465,0.0002069283],"genre_scores_gemma":[0.8766641,0.0001388594,0.001565688,0.00008994839,0.0002095377,0.0002407009,0.1185528,0.00004171056,0.002496669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03891957,"threshold_uncertainty_score":0.9991263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03376233123090575,"score_gpt":0.2959059747716981,"score_spread":0.2621436435407923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}