{"id":"W4362451642","doi":"10.1158/1078-0432.ccr-22-3136","title":"Safety and Efficacy of Axicabtagene Ciloleucel versus Standard of Care in Patients 65 Years of Age or Older with Relapsed/Refractory Large B-Cell Lymphoma","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Cancer Institute; Gilead Sciences","keywords":"Medicine; Chemoimmunotherapy; Clinical endpoint; Internal medicine; Adverse effect; Oncology; Randomized controlled trial; Surgery; Lymphoma; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001074681,0.000382558,0.0009987626,0.0002880893,0.0001869926,0.0005077232,0.000270334,0.0004880971,0.001644879],"category_scores_gemma":[0.001356309,0.0001799328,0.001156536,0.0002355718,0.0003846413,0.0003642885,0.0002635892,0.0006969168,0.0001878411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004764745,"about_ca_system_score_gemma":0.0004772839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004593981,"about_ca_topic_score_gemma":0.00144701,"domain_scores_codex":[0.9995645,0.0002319542,0.00003822755,0.0000536468,0.00003897134,0.00007269156],"domain_scores_gemma":[0.9994518,0.000172401,0.0001722409,0.0000362081,0.00001994767,0.0001473854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9157548,0.004633712,0.02687952,0.0003399355,0.001488693,0.0001103413,0.00008687265,0.000737215,0.006448188,0.00006867456,0.0003789981,0.04307302],"study_design_scores_gemma":[0.2769336,0.5774661,0.1318776,0.0001168446,0.003729363,0.0004284695,0.0002774448,0.00311764,0.003613658,0.0003783138,0.002017063,0.00004397581],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984025,0.001041655,0.00004597889,0.00007302475,0.00002269838,0.00006713519,0.00008196265,0.000005303954,0.0002596407],"genre_scores_gemma":[0.9991008,0.000320932,0.00007871012,0.0001183907,0.00004226679,0.00006158468,0.0001138412,0.000001244538,0.0001621618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644879,"threshold_uncertainty_score":0.005683541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042572875667361,"score_gpt":0.4631420898558782,"score_spread":0.3588848022891421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}