{"id":"W4362451642","doi":"10.1158/1078-0432.ccr-22-3136","title":"Safety and Efficacy of Axicabtagene Ciloleucel versus Standard of Care in Patients 65 Years of Age or Older with Relapsed/Refractory Large B-Cell Lymphoma","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Cancer Institute; Gilead Sciences","keywords":"Medicine; Chemoimmunotherapy; Clinical endpoint; Internal medicine; Adverse effect; Oncology; Randomized controlled trial; Surgery; Lymphoma; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002840907,0.0001418173,0.0008675065,0.0004317719,0.00003960098,0.000007217687,0.00026529,0.0002270747,0.0007605805],"category_scores_gemma":[0.001319446,0.0001123109,0.0001323798,0.001361887,0.0008182463,0.00004587193,0.0003182619,0.0006548512,0.000009004572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003034369,"about_ca_system_score_gemma":0.001341744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003816168,"about_ca_topic_score_gemma":0.0008729669,"domain_scores_codex":[0.9957775,0.0005197286,0.0008608291,0.0004849845,0.001777618,0.0005793806],"domain_scores_gemma":[0.995661,0.002416512,0.0001540723,0.0006636803,0.0008361401,0.0002685762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4725964,0.003551063,0.2684242,0.002056783,0.0002959027,0.0003130044,0.002690224,0.00001160376,0.002892339,0.00002443364,0.001920893,0.2452232],"study_design_scores_gemma":[0.09835338,0.02138676,0.8583246,0.0007420632,0.00004253005,3.434392e-7,0.001104705,0.00001641652,0.004617418,0.000004896298,0.0152667,0.0001402326],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996278,0.0009867362,9.770783e-7,0.0001158115,0.0001132113,0.00101711,0.0002415044,0.00001510338,0.001231503],"genre_scores_gemma":[0.9916769,0.005670786,0.00005270603,0.00001524442,0.00008576008,0.00002974003,0.0000556023,0.00005244383,0.002360844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5899003,"threshold_uncertainty_score":0.8327823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042572875667361,"score_gpt":0.4631420898558782,"score_spread":0.3588848022891421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}