{"id":"W4362455037","doi":"10.1111/jne.13271","title":"Palmitate alters <scp>miR</scp>‐2137 and <scp>miR</scp>‐503‐5p to induce orexigenic <i>Npy</i> in hypothalamic neuronal cell models: Rescue by oleate and docosahexaenoic acid","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroendocrinology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Orexigenic; Internal medicine; Endocrinology; Docosahexaenoic acid; Chemistry; Energy homeostasis; Unfolded protein response; microRNA; Neuropeptide Y receptor; Downregulation and upregulation; Neuropeptide; Biology; Cell biology; Fatty acid; Polyunsaturated fatty acid; Endoplasmic reticulum; Biochemistry; Medicine; Receptor; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588998,0.0004209928,0.0004685536,0.000268975,0.0003083951,0.0003186769,0.0002285749,0.0003381196,0.001630133],"category_scores_gemma":[0.0001265254,0.0002840146,0.0006473335,0.0002620559,0.0003584498,0.0002245302,0.0002710993,0.0007878371,0.0006108019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004231028,"about_ca_system_score_gemma":0.0005301779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00198511,"about_ca_topic_score_gemma":0.003076019,"domain_scores_codex":[0.999783,0.00002227316,0.00003186587,0.00004988292,0.0000475138,0.00006548524],"domain_scores_gemma":[0.9998982,0.00001486403,0.00002815182,0.00001262021,0.00001399508,0.00003223002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000483798,0.00004703755,0.0001528484,0.0000389827,0.00001262292,0.00004811068,0.0000189135,0.00004701082,0.998322,0.00006307238,0.00007907089,0.0006865201],"study_design_scores_gemma":[0.00002915079,0.0002595395,0.00323707,0.000005265798,0.00003374702,0.0001090452,0.00004503108,0.0005657721,0.9934356,0.00004852712,0.002224675,0.000006692888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991576,0.001800522,0.002262074,0.0002713897,0.0001381794,0.00005226334,0.001470133,0.0001676777,0.002261792],"genre_scores_gemma":[0.9872842,0.001580962,0.003240114,0.0002715113,0.00001810404,0.0001708625,0.002091097,0.00009449136,0.005248789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00198511,"threshold_uncertainty_score":0.005453348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607748871524028,"score_gpt":0.2379911791390103,"score_spread":0.22191369042377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}