{"id":"W4362457702","doi":"10.1158/1078-0432.ccr-22-2998","title":"Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Cilag; Astellas Pharma; Killam Trusts; ZonMw; Prostate Cancer Foundation","keywords":"Enzalutamide; Abiraterone; Prostate cancer; Medicine; Oncology; Cancer; Internal medicine; Prostate; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122496,0.0002550135,0.0004002582,0.000320207,0.0001998655,0.0004964073,0.0003772203,0.0004248137,0.0008242697],"category_scores_gemma":[0.003210905,0.000169434,0.000378368,0.0004136358,0.0002769484,0.0003406909,0.000273519,0.0004933079,0.0001208452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005889589,"about_ca_system_score_gemma":0.0003699286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001431374,"about_ca_topic_score_gemma":0.002012397,"domain_scores_codex":[0.9993793,0.000214598,0.00005592296,0.0001512529,0.0001348514,0.0000640919],"domain_scores_gemma":[0.9967589,0.0007664468,0.001873753,0.0001806924,0.0001565899,0.0002636931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005699666,0.0001612505,0.9827135,0.00004291781,0.0001741739,0.00006500928,0.00004993817,0.0002441719,0.002830429,0.00001118961,0.00007535255,0.007932563],"study_design_scores_gemma":[0.00006402518,0.0009753383,0.9975299,0.000006751114,0.00007247168,0.0001924825,0.00002782256,0.0003637676,0.0005957397,0.00001982678,0.0001474385,0.000004319444],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992352,0.0004464538,0.00006694958,0.00001705703,0.000002569817,0.000006551846,0.0001261967,0.000004008827,0.00009509268],"genre_scores_gemma":[0.9996233,0.00006993171,0.00004924737,0.00001484187,0.000004862664,0.000004041611,0.0001809228,0.000001270764,0.00005144873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431374,"threshold_uncertainty_score":0.005936384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3526424261395648,"score_gpt":0.5554773306580965,"score_spread":0.2028349045185316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}