{"id":"W4362457718","doi":"10.1038/s41594-023-00957-1","title":"Mapping the conformational landscape of the stimulatory heterotrimeric G protein","year":2023,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Heterotrimeric G protein; G protein; Allosteric regulation; Chemistry; Biophysics; G protein-coupled receptor; Lipid bilayer; G alpha subunit; Protein subunit; Helix (gastropod); Biochemistry; Signal transduction; Receptor; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810837,0.000152672,0.0001419439,0.00005119793,0.000145924,0.00001217658,0.0004231994,0.0003468585,0.00005019487],"category_scores_gemma":[0.0001080021,0.00008272611,0.000168651,0.0002856887,0.0001281049,0.000003024502,0.0002053294,0.0003076827,0.000004466994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006089639,"about_ca_system_score_gemma":0.00006104495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005038254,"about_ca_topic_score_gemma":0.000001274268,"domain_scores_codex":[0.9990364,0.0001375205,0.0002209533,0.0002235858,0.0001438434,0.0002377237],"domain_scores_gemma":[0.9993694,0.00001209629,0.0001527193,0.0003389815,0.00009644494,0.00003031209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001882875,0.000001494683,0.000316725,0.00001060128,0.00005472992,6.674871e-7,0.00003794745,0.0003535376,0.9947701,0.003321313,0.0002669139,0.0008471128],"study_design_scores_gemma":[0.000376878,0.0001018958,0.005099822,0.00001538774,0.000009848029,0.00002085658,0.00009803348,0.000820061,0.9831414,0.002707463,0.007439041,0.0001693442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965289,0.001031169,0.0009607341,0.0004683408,0.0004246155,0.0003709992,0.00003092078,0.0000169058,0.000167438],"genre_scores_gemma":[0.9987444,0.000007828648,0.0002424095,0.0005814235,0.0001284458,0.00002033348,0.000157172,0.00001385981,0.0001041556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01162876,"threshold_uncertainty_score":0.3373473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007006666051088699,"score_gpt":0.2614743101595037,"score_spread":0.254467644108415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}