{"id":"W4362458580","doi":"10.1038/s41586-023-06003-w","title":"Genomic investigations of unexplained acute hepatitis in children","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Genetics; NIHR Great Ormond Street Hospital Biomedical Research Centre; National Cheng Kung University; Universität Zürich; Great Ormond Street Hospital for Children; Newcastle upon Tyne Hospitals NHS Foundation Trust; Public Health England; Great Ormond Street Institute of Child Health; Newcastle University; Universiteit van Amsterdam; Sheffield Teaching Hospitals NHS Foundation Trust; European Commission; Radboud Universiteit; National Institute for Health Research Health Protection Research Unit; University of Oxford; Cancer Research UK; Wellcome Trust; Imperial College Healthcare NHS Trust; University College London; CHILDREN with CANCER UK; King's College London; Medizinische Universität Graz; Imperial College London; NHS Blood and Transplant; National Institute for Health and Care Research; St. Antonius Ziekenhuis; UK Research and Innovation; Northumbria University; University of Otago; Medical Research Council; Univerza v Ljubljani; Department of Health and Social Care; Deutsches Zentrum für Infektionsforschung; Karl-Franzens-Universität Graz; McGill University; London School of Hygiene and Tropical Medicine","keywords":"Acute hepatitis; Medicine; Genetics; Hepatitis; Biology; Virology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563521,0.00005566255,0.000195473,0.0002049677,0.00001661483,0.000002003388,0.00007132126,0.0003155532,0.00004644697],"category_scores_gemma":[0.0004058036,0.00004856722,0.00004617058,0.0003778937,0.00006676558,0.00002719809,0.00004399749,0.000895739,0.0000455234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003184854,"about_ca_system_score_gemma":0.00004946774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001727874,"about_ca_topic_score_gemma":0.0001361325,"domain_scores_codex":[0.9993467,0.00004901741,0.0001606774,0.0001231372,0.0001044499,0.0002160535],"domain_scores_gemma":[0.9997036,0.00001557524,0.00002835022,0.0001303613,0.00003356924,0.00008857666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003862487,0.00001476144,0.964834,0.00001254801,0.00004366229,0.00003626787,0.00003297107,0.000009831898,0.01588228,0.0001757353,0.01844668,0.0004726569],"study_design_scores_gemma":[0.0007082678,0.0001515782,0.9973403,0.00004227568,0.000009191665,0.00004411405,0.000007108607,0.0002383302,0.0003644084,0.0004505074,0.0006161142,0.00002779247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922186,0.0001670333,0.000004803235,0.006959163,0.00004359584,0.0002017019,0.00007579486,0.00003436876,0.000295002],"genre_scores_gemma":[0.996728,0.0005308413,0.0006679604,0.001275642,0.00006377859,0.0000153823,0.0003854893,0.000008516965,0.0003244155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03250633,"threshold_uncertainty_score":0.389159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330815991294881,"score_gpt":0.3156862193483018,"score_spread":0.302378059435353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}