{"id":"W4362458580","doi":"10.1038/s41586-023-06003-w","title":"Genomic investigations of unexplained acute hepatitis in children","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Genetics; NIHR Great Ormond Street Hospital Biomedical Research Centre; National Cheng Kung University; Universität Zürich; Great Ormond Street Hospital for Children; Newcastle upon Tyne Hospitals NHS Foundation Trust; Public Health England; Great Ormond Street Institute of Child Health; Newcastle University; Universiteit van Amsterdam; Sheffield Teaching Hospitals NHS Foundation Trust; European Commission; Radboud Universiteit; National Institute for Health Research Health Protection Research Unit; University of Oxford; Cancer Research UK; Wellcome Trust; Imperial College Healthcare NHS Trust; University College London; CHILDREN with CANCER UK; King's College London; Medizinische Universität Graz; Imperial College London; NHS Blood and Transplant; National Institute for Health and Care Research; St. Antonius Ziekenhuis; UK Research and Innovation; Northumbria University; University of Otago; Medical Research Council; Univerza v Ljubljani; Department of Health and Social Care; Deutsches Zentrum für Infektionsforschung; Karl-Franzens-Universität Graz; McGill University; London School of Hygiene and Tropical Medicine","keywords":"Acute hepatitis; Medicine; Genetics; Hepatitis; Biology; Virology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000273788,0.0003609173,0.0002190267,0.001267788,0.0005122196,0.0003009329,0.0001742236,0.0002844048,0.001514424],"category_scores_gemma":[0.001275647,0.0001944755,0.0001483747,0.0006614326,0.0005402607,0.0003024026,0.0003774815,0.0002070649,0.0002166407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002213685,"about_ca_system_score_gemma":0.0002987398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001895466,"about_ca_topic_score_gemma":0.001597909,"domain_scores_codex":[0.9996645,0.00008314242,0.00003740364,0.00007105291,0.00008110025,0.00006268304],"domain_scores_gemma":[0.9993908,0.0001315242,0.0002899922,0.00003522378,0.00005478382,0.00009758395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004336089,0.00001327602,0.9896101,0.00003774863,0.00001005103,0.004032419,0.0003463114,0.00003620814,0.002571485,0.00005934939,0.0001067793,0.003132937],"study_design_scores_gemma":[0.000003712327,0.0001773528,0.9578605,0.00002060206,0.00001892228,0.03763669,0.0009963968,0.00007759623,0.001741055,0.00007800282,0.001384404,0.000004780882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976665,0.0006583216,0.000251434,0.00005150466,0.000005640232,0.00001732706,0.0002355272,0.00001272922,0.001101191],"genre_scores_gemma":[0.9989154,0.0003753945,0.0003377523,0.00003881174,0.000009101999,0.000008751378,0.0001592872,0.00000417285,0.000151406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001895466,"threshold_uncertainty_score":0.005066276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330815991294881,"score_gpt":0.3156862193483018,"score_spread":0.302378059435353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}