{"id":"W4362459564","doi":"10.1182/blood.2023019765","title":"Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Eye Institute; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Institute of Environmental Health Sciences; American Lebanese Syrian Associated Charities; NIH Office of the Director; National Heart, Lung, and Blood Institute; McGill University; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense","keywords":"Biology; Genetics; CEBPA; Transcriptome; Enhancer; Copy-number variation; Gene; Cancer research; Genome; Mutation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003506432,0.0002307569,0.0006215539,0.0004306448,0.00007731796,0.00001847865,0.0002779221,0.0002278352,0.0003228622],"category_scores_gemma":[0.0004385189,0.0002012067,0.0001807588,0.001247209,0.0001268152,0.00005689849,0.0002258792,0.0002169194,0.001245759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713389,"about_ca_system_score_gemma":0.001540601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008502757,"about_ca_topic_score_gemma":0.000007661553,"domain_scores_codex":[0.9977344,0.00005847546,0.000452371,0.0003943867,0.000683928,0.0006764057],"domain_scores_gemma":[0.998557,0.0003429181,0.0001407563,0.0005222314,0.0001670365,0.000270055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001415374,0.002805131,0.3340305,0.001338263,0.01078741,0.02098858,0.001716415,0.0003663202,0.5547574,0.0004119527,0.06952196,0.001860686],"study_design_scores_gemma":[0.04120675,0.002160416,0.9141436,0.0006121108,0.002789834,0.003765712,0.0002829622,0.00997584,0.02346633,0.000246929,0.0006933744,0.000656098],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953509,0.0001162102,0.00002540952,0.0001759204,0.0001193453,0.0003851822,0.0001019855,0.0003133664,0.003411711],"genre_scores_gemma":[0.9954764,0.0001548508,0.0001676985,0.00009856049,0.00007720973,0.00003908758,0.0001969534,0.00007031676,0.003718893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5801131,"threshold_uncertainty_score":0.9995319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194295069340883,"score_gpt":0.2555919687781071,"score_spread":0.2436490180846982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}