{"id":"W4362459564","doi":"10.1182/blood.2023019765","title":"Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Eye Institute; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Institute of Environmental Health Sciences; American Lebanese Syrian Associated Charities; NIH Office of the Director; National Heart, Lung, and Blood Institute; McGill University; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense","keywords":"Biology; Genetics; CEBPA; Transcriptome; Enhancer; Copy-number variation; Gene; Cancer research; Genome; Mutation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134191,0.0001414768,0.0002241119,0.0007159075,0.0001979113,0.0003521154,0.0001295804,0.0001377335,0.0009096152],"category_scores_gemma":[0.0003990493,0.0001009536,0.0002132315,0.0007517801,0.0001327955,0.0001203221,0.0003141413,0.0001587202,0.0002142484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022139,"about_ca_system_score_gemma":0.0001514553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571629,"about_ca_topic_score_gemma":0.002414742,"domain_scores_codex":[0.9998206,0.00002272763,0.00001013409,0.00008012237,0.00003312937,0.00003326443],"domain_scores_gemma":[0.9998746,0.00003260476,0.000039687,0.00001004734,0.00002283236,0.00002019419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009139925,0.00004233358,0.4457615,0.0004522439,0.00033552,0.001533247,0.000869336,0.002456866,0.5019205,0.0009817939,0.002740418,0.04199217],"study_design_scores_gemma":[0.00002027565,0.00007226387,0.9673997,0.00003685256,0.0001674922,0.001950918,0.0005013607,0.004409165,0.01492966,0.0009945007,0.009495768,0.00002202032],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918573,0.0009108013,0.001571862,0.00007232386,0.000005237564,0.0000104263,0.004439349,0.00006416436,0.001068522],"genre_scores_gemma":[0.9875374,0.0005433382,0.001777304,0.0001079798,0.000008540633,0.00002472828,0.009430581,0.00004941848,0.0005207299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001571629,"threshold_uncertainty_score":0.003125012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194295069340883,"score_gpt":0.2555919687781071,"score_spread":0.2436490180846982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}