{"id":"W4362466221","doi":"10.3390/v15040893","title":"Validation of HIV-1 MA Shell Structural Arrangements and Env Protein Interactions Predict a Role of the MA Shell in Viral Maturation","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Northern Alberta Institute of Technology; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Shell (structure); Glycoprotein; Virus; Viral envelope; Viral entry; Biology; Viral matrix protein; Biophysics; Protein structure; Human immunodeficiency virus (HIV); Cluster (spacecraft); Protein domain; Fusion; Chemistry; Virology; Physics; Cell biology; Genetics; Viral replication; Materials science; Computer science; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241033,0.0002005409,0.0001207102,0.0001765137,0.0003445609,0.0002678855,0.0002857074,0.0002838322,0.0006139641],"category_scores_gemma":[0.0005097674,0.0001525097,0.0001724423,0.000151823,0.0003112713,0.0003902298,0.000261421,0.0003648397,0.0001282727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617371,"about_ca_system_score_gemma":0.00009850078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009971453,"about_ca_topic_score_gemma":0.0009251058,"domain_scores_codex":[0.9999045,0.0000177886,0.000008073533,0.00002405026,0.00002784985,0.00001762578],"domain_scores_gemma":[0.999747,0.00006050606,0.00006444258,0.00005430296,0.00005098893,0.00002272435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000977227,0.00003181475,0.01466452,0.0000484576,0.00001573225,0.0001501305,0.000188787,0.0008789434,0.9805636,0.0002548463,0.00002341108,0.003081866],"study_design_scores_gemma":[0.000005889524,0.0002459754,0.1180161,0.000009933991,0.00003680409,0.0006979901,0.0003764871,0.01292967,0.8664322,0.0002866575,0.0009466432,0.00001573922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973925,0.0001525763,0.002005518,0.000009959927,0.000001712776,0.000007515896,0.00004976697,0.00001763375,0.0003627118],"genre_scores_gemma":[0.995983,0.00007038907,0.003692134,0.000005997238,7.17684e-7,0.000004338536,0.0001055339,0.00000512833,0.0001327676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009971453,"threshold_uncertainty_score":0.002053916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741228823999543,"score_gpt":0.27544539125504,"score_spread":0.2580331030150446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}