{"id":"W4362466334","doi":"10.31665/jfb.2023.18341","title":"Biomolecular interactions and inhibition kinetics of human soluble epoxide hydrolase by tetrapeptide YMSV","year":2023,"lang":"en","type":"article","venue":"Journal of Food Bioactives","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"University of Ottawa","keywords":"Epoxide hydrolase 2; Tetrapeptide; Chemistry; IC50; Stereochemistry; Peptide; Hydrogen bond; Docking (animal); Kinetics; Circular dichroism; Enzyme; Biochemistry; In vitro; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291227,0.0001525338,0.0001409169,0.00005974948,0.00004969946,0.00009603032,0.0001023021,0.0001428862,0.0006140779],"category_scores_gemma":[0.0001956631,0.00007063954,0.0001614488,0.00006449164,0.0001026787,0.0001322254,0.00006145649,0.0002645419,0.000149526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001252761,"about_ca_system_score_gemma":0.00006954266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003362549,"about_ca_topic_score_gemma":0.0002220722,"domain_scores_codex":[0.9999378,0.00001351739,0.000004733523,0.00001535172,0.00001463984,0.0000139305],"domain_scores_gemma":[0.9999255,0.00002375801,0.0000257658,0.000002927422,0.000008373669,0.00001375095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003609185,0.0000385141,0.0005990194,0.00004383591,0.00001579763,0.00004070796,0.00001648893,0.0005425052,0.9958032,0.00007296812,0.00005868837,0.00240747],"study_design_scores_gemma":[0.00002565942,0.0008460529,0.004381305,0.000004266719,0.0000143955,0.0001186369,0.00001710923,0.005596945,0.9882222,0.00003538292,0.0007312725,0.000006806322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971579,0.001341086,0.001112903,0.00002273242,0.000009820254,0.00000671331,0.00007595155,0.000009971049,0.0002628792],"genre_scores_gemma":[0.9972454,0.0006878955,0.001284196,0.00002846505,0.000006230067,0.00001141024,0.0001809607,0.000004417951,0.000550965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006140779,"threshold_uncertainty_score":0.002054274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629321747368543,"score_gpt":0.2912353936434212,"score_spread":0.2749421761697358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}